Table 1.
Clinical and baseline demographic characteristics of all participants
| Cohort | Group | Sex (M/F) | Age (years) | Education (years) | MMSE score | APOE ε4 positive rate | |
|---|---|---|---|---|---|---|---|
| Cohort A |
Training dataset (n = 255) |
sMCI (n = 166) | 90/76 | 71.2 ± 7.81 | 16.1 ± 2.62 | 28.4 ± 1.51 | 45.2% |
| pMCI (n = 89) | 52/37 | 73.2 ± 7.56 | 16.4 ± 2.47 | 26.9 ± 1.54 | 64.1% | ||
| P value | 0.52a | 0.045b | 0.36c | < 0.001b | 0.0041a | ||
|
Test dataset (n = 255) |
sMCI (n = 166) | 85/81 | 70.6 ± 6.81 | 16.1 ± 2.64 | 28.4 ± 1.53 | 34.3% | |
| pMCI (n = 89) | 50/39 | 74.1 ± 6.21 | 15.5 ± 2.79 | 27.1 ± 2.03 | 73.0% | ||
| P value | 0.45a | 0.01b | 0.11c | <0.001b | <0.001a | ||
| Cohort B | HC (n = 50) | 24/26 | 74.6 ± 3.17 | 15.8 ± 2.53 | 29.1 ± 1.01 | 28% | |
| AD (n = 50) | 28/22 | 74.8 ± 2.75 | 15.7 ± 2.64 | 23.1 ± 2.23 | 74% | ||
| P value | 0.55a | 0.71b | 0.87c | < 0.001b | < 0.001a | ||
Pa, the chi-square test; Pb, the two-sample t test; Pc, the Wilcoxon rank-sum test. sMCI, stable MCI; pMCI, progressive MCI; MMSE, mini-mental state examination; APOE ε4 positive rate, positive or negative for the presence of at least one ε4 allele
Data are given as mean ± SD