Figure 2.

Interactions in the wild-type (WT) (PDB ID: 1JPS²²) and the double-point mutant model. (a) The interactions common to the WT and the mutant are depicted in the WT structure. (b) Interactions specific to the WT are depicted in the WT structure. (c) Interactions common to the WT and the mutant are depicted in the mutant structure. (d) Interactions specific to the mutant are depicted in the mutant structure. Light (L) chain, heavy (H) chain, and antigen are colored in green, cyan, and magenta, respectively. Interactions are depicted in yellow dashed lines. Water molecules are depicted by red spheres. The interactions of the rest of the DP mutants are given in Figs. S2–4.