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. 2020 Oct 16;11:5236. doi: 10.1038/s41467-020-19048-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A-to-I RNA editing levels in evolutionary conserved coding editing sites in the brains of healthy mouse embryos during brain development (n = 4 for days 11.5–17.5, n = 3 for days 10.5 and 18.5). Levels of RNA editing from PolyI:C (n = 8) and control (n = 11) mice from the MIA model are indicated on GD10 when the brains were sequenced. The top four recoding editing sites that showed the largest change in editing levels in the MIA model are a COG3 (chr14:75719719), b DACT3 (chr7:16885347), c BLCAP (chr2:157558110), and d BLCAP (chr2:157558140). Editing level is indicated only when sufficiently expressed (see “Methods”). All values are means ± SEM. Source data are provided as a Source Data file.