Table 1.
dMRI metrics with significant differences between age-comparable healthy controls and NMDCCC patients with mild or severe compression.
| Parameter | Shortcut | HARDI-ZOOMit Interp. | DTI-RESOLVE non-Interp. | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Mild Comp. patients | Severe Comp. patients | Control | Mild Comp. patients | Severe Comp. patients | ||||||||||
| Median | Median | diff % | p value | Median | diff % | p value | Median | Median | diff % | p value | Median | diff % | p value | ||
| FA_WM_STD | FAwS | 0.1422 | 0.1286 | − 9.60 | 6.10E−3 | 0.1356 | − 4.65 | 5.30E−2 | 0.1266 | 0.1239 | − 2.11 | 4.12E−1 | 0.1325 | 4.72 | 1.00E+1 |
| FA_WM_kurtosis | FAwK | 2.4934 | 2.8241 | 13.26 | 5.35E−4 | 2.6698 | 7.07 | 1.66E−2 | 2.7666 | 2.8592 | 3.35 | 8.89E−1 | 2.7658 | − 0.03 | 5.19E−1 |
| f1_WM_STD | f1wS | 0.1512 | 0.1323 | − 12.55 | 6.10E−3 | 0.1397 | − 7.61 | 1.29E−2 | 0.1398 | 0.1318 | − 5.71 | 2.54E−1 | 0.1304 | − 6.75 | 2.49E−1 |
| f1_WM_skewness | f1wSK | − 0.1315 | − 0.0805 | − 38.82 | 6.74E−1 | 0.0313 | − 123 | 6.57E−3 | − 0.0685 | − 0.0078 | − 88.68 | 5.89E−1 | 0.1390 | − 303 | 1.67E−1 |
| f1_WM_kurtosis | f1wK | 2.4683 | 2.7209 | 10.23 | 1.82E−4 | 2.7330 | 10.72 | 3.20E−3 | 2.6254 | 2.6115 | − 0.53 | 6.74E−1 | 2.7310 | 4.02 | 8.90E−1 |
| MD_WM_median | MDwM | 1.0509 | 0.9951 | − 5.31 | 5.40E−3 | 1.0578 | 0.65 | 4.61E−1 | 1.1614 | 1.1860 | 2.12 | 5.62E−1 | 1.2524 | 7.83 | 1.29E−2 |
| MD_WM_mean | MDwm | 1.1545 | 1.0576 | − 8.39 | 2.51E−3 | 1.1005 | − 4.68 | 1.97E−1 | 1.2414 | 1.2345 | − 0.56 | 7.64E−1 | 1.3230 | 6.58 | 2.40E−2 |
| MD_WM_STD | MDwS | 0.3561 | 0.2621 | − 26.39 | 1.10E−3 | 0.2863 | − 19.60 | 2.28E−4 | 0.3069 | 0.2708 | − 11.76 | 3.56E−2 | 0.3150 | 2.64 | 9.63E−1 |
| d_WM_STD | dwS | 0.4893 | 0.4325 | − 11.62 | 4.77E−3 | 0.4545 | − 7.11 | 2.69E−1 | 0.3727 | 0.3544 | − 4.89 | 1.93E−1 | 0.4238 | 13.72 | 7.12E−1 |
| d_WM_skewness | dwSK | 1.1506 | 1.1119 | − 3.36 | 9.20E−1 | 0.9342 | − 18.80 | 6.57E−3 | 0.1457 | 0.2125 | 45.86 | 4.35E−1 | 0.2112 | 44.99 | 3.57E−1 |
| MD_GM_median | MDgm | 0.8300 | 0.8406 | 1.28 | 2.38E−1 | 0.8933 | 7.64 | 4.95E−3 | 1.0577 | 1.1145 | 5.37 | 4.75E−2 | 1.1772 | 11.29 | 4.95E−3 |
| MD_GM_mean | MDgm | 0.8573 | 0.8633 | 0.70 | 4.35E−1 | 0.9048 | 5.53 | 1.46E−2 | 1.0657 | 1.1255 | 5.61 | 2.63E−2 | 1.1975 | 12.37 | 2.03E−3 |
| MD_GM_skewness | MDgSK | 1.6110 | 1.4599 | − 9.38 | 6.17E−1 | 1.2434 | − 22.81 | 5.89E−2 | 0.0600 | 0.5163 | 760 | 7.76E−3 | 0.6187 | 931 | 1.07E−3 |
| d_GM_median | dgM | 1.4979 | 1.5211 | 1.55 | 5.22E−2 | 1.6111 | 7.56 | 6.57E−3 | 1.9277 | 1.9717 | 2.29 | 2.63E−2 | 2.0262 | 5.11 | 1.26E−3 |
| d_GM_mean | dgm | 1.5401 | 1.5595 | 1.26 | 3.92E−2 | 1.6498 | 7.13 | 2.75E−3 | 1.8827 | 1.9816 | 5.26 | 1.54E−2 | 2.0449 | 8.62 | 5.50E−4 |
| MD_WM-GM_median | MDwgM | 0.2122 | 0.1470 | − 30.71 | 8.04E−5 | 0.1711 | − 19.35 | 1.88E−2 | 0.1185 | 0.0913 | − 23.00 | 9.82E−3 | 0.1032 | − 12.94 | 2.14E−1 |
| MD_WM-GM_mean | MDwgm | 0.2803 | 0.1906 | − 32.00 | 6.80E−5 | 0.1990 | − 29.00 | 1.90E−4 | 0.1676 | 0.1172 | − 30.09 | 1.27E−3 | 0.1244 | − 25.82 | 3.41E−2 |
| d_WM-GM_median | dwgM | 0.5129 | 0.4339 | − 15.41 | 1.32E−4 | 0.4122 | − 19.63 | 1.48E−3 | 0.3864 | 0.3446 | − 10.82 | 4.32E−2 | 0.2546 | − 34.11 | 4.29E−3 |
| d_WG-GM_mean | dwgm | 0.5676 | 0.4580 | − 19.31 | 2.41E−5 | 0.4321 | − 23.87 | 2.28E−4 | 0.3823 | 0.3340 | − 12.64 | 5.72E−2 | 0.2373 | − 37.92 | 3.71E−3 |
| FA_WM_heuristic | FAwH | 0.4729 | 0.5076 | 7.36 | 2.63E−2 | 0.5349 | 13.13 | 6.52E−4 | 0.5467 | 0.5569 | 1.87 | 6.74E−1 | 0.5412 | − 1.00 | 6.45E−1 |
| f1_WM_heuristic | f1wH | 0.5362 | 0.5819 | 8.52 | 4.21E−3 | 0.5897 | 9.98 | 4.29E−3 | 0.5789 | 0.5941 | 2.64 | 7.64E−1 | 0.5505 | − 4.90 | 4.07E−1 |
| MD_WM_heuristic | MDwH | 0.5683 | 0.6706 | 17.99 | 7.18E−4 | 0.6403 | 12.67 | 3.20E−3 | 0.5432 | 0.5755 | 5.94 | 4.84E−1 | 0.4757 | − 12.42 | 6.54E−2 |
| d_WM_heuristic | dwH | 0.5002 | 0.5513 | 10.21 | 6.10E−3 | 0.5023 | 0.43 | 9.27E−1 | 0.3799 | 0.3538 | − 6.86 | 4.12E−1 | 0.3411 | − 10.22 | 3.11E−1 |
| MD_GM_heuristic | MDgH | 0.4956 | 0.5400 | 8.96 | 1.05E−1 | 0.5892 | 18.90 | 1.48E−3 | 0.7732 | 0.7345 | − 5.00 | 4.59E−1 | 0.6435 | − 16.78 | 4.95E−3 |
| d_GM_heuristic | dgH | 0.4872 | 0.4550 | − 6.60 | 9.66E−2 | 0.3537 | − 27.41 | 5.71E−3 | 0.0774 | 0.0533 | − 31.08 | 5.22E−2 | 0.0527 | − 31.82 | 1.53E−1 |
List of parameters with their corresponding labels as used in Fig. 6 along with statistics and Wilcoxon rank-sum test p values for HARDI-ZOOMit Interp and DTI-RESOLVE Non-Interp protocols. Significant p values () are highlighted in bold.