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. 2020 Oct 16;3:578. doi: 10.1038/s42003-020-01301-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Numbers and types of germline variants identified in each gene. b Box-and-whisker plots of age at breast cancer diagnosis for tumors with germline variants (n = 101), including BRCA1 (n = 15), BRCA2 (n = 62), and others (n = 24), and those without (n = 1892). The boxes indicating median and interquartile range, and the whiskers denoting the range. Asterisks indicate significance difference (Mann–Whitney U test: P < 0.05). c Distribution of phenotype according to the status of germline mutations. DCIS ductal carcinoma in situ, TNBC triple-negative breast cancer, LumHER2 luminalHer2. d Distribution of t factor for tumors according to the status of germline mutations. Tis carcinoma in situ.