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. 2020 Oct 16;3:578. doi: 10.1038/s42003-020-01301-9

Fig. 2. Genetic landscape of breast cancers with pathogenic germline variants in BRCA1/2.

Fig. 2

a Numbers of driver mutations in tumors with germline variants in BRCA1/2 (n = 30) and those without (n = 30). Asterisks indicate significance difference (Mann–Whitney U test: P < 0.05). b The landscape of somatic variants in tumors with germline variants in BRCA1/2 (n = 30) and those without (n = 30). Distribution and types of recurrently mutated genes in tumors with germline BRCA1/2 mutations are shown. c Genome-wide CN changes in tumors with germline variants in BRCA1/2. Red: gain, dark red: gain with LOH, green: copy neutral LOH, blue: deletion. d Representative CN plots of tumors with and without biallelic inactivation. Regions with LOH are shown in orange lines. CN copy number, AsCN allele specific CN.