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. 2020 Oct 16;3:578. doi: 10.1038/s42003-020-01301-9

Fig. 3. Genetic characteristics of breast tumors harboring germline BRCA1/2 mutations with and without biallelic inactivation.

Fig. 3

a Types of germline variants in BRCA1/2 according to the status of biallelic inactivation (n = 64). b Fraction of genomic regions with LOH in tumors without germline variants (n = 30) and in those harboring germline BRCA1 mutations with (n = 18) and without (n = 3) biallelic inactivation and those with germline BRCA2 mutations with (n = 31) and without (n = 12) biallelic inactivation. Asterisks indicate significance difference (Mann–Whitney U test: P < 0.05). c Frequency of TP53 mutations in tumors without germline variants (n = 30) and those harboring germline BRCA1/2 mutations with and without biallelic inactivation (n = 64). Asterisks indicate a significance difference (Fisher test: P < 0.05). d LOHs on chromosome 17 in patients with germline BRCA1 mutations (n = 17). LOHs identified in a single patient are shown on a line. e LOHs on chromosome 13 in patients with germline BRCA2 mutations (n = 3).