Fig. 6. 38-1-10A and 38-3-11A interact with the same epitope of EV71.

The core region of the epitope that interacts with 38-1-10A (a) and with 38-3-11A (b). Capsid proteins of EV71 are shown as ribbons with VP1, VP2 and VP3 coloured in light blue, pale green and salmon, respectively. C_αs of viral residues that have direct contact with CDR H3 or L3 (≤4.0 Å) are drawn as bright spheres. The core region of one epitope is circled and black lines mark the pentamer boundaries. c, d Roadmaps of the virus surface with colour scheme as in a and an icosahedral subunit outlined in black lines. Residues in contact with 38-1-10A (c) or 38-3-11A (d) are highlighted in the corresponding viral protein colour and escape mutations are shown in bright colours.