Table 3.

Main effect of examined SNPs on depression score in different groups based on linear regression analysis^∗.

Gene	SNP (MiA/MaA)	Modela	Total (N = 623)		Women (N = 504)		Men (N = 117)		Russians (N = 225)		Udmurts (N = 218		Tatars (N = 141)
			β	P-value	β	P-value	β	P-value	β	P-value	β	P-value	β	P-value
AVPR1A	rs3803107 A/G	dominant	1.241	0.046	1.468	0.035	0.763	0.570	3.596	0.003b	-0.059	0.948	0.080	0.941
AVPR1B	rs1042615 A/G	additive	-0.139	0.748	0.091	0.850	-1.330	0.164	-0.929	0.225	0.056	0.929	-0.466	0.602
	rs33911258 G/A	domdev	0.711	0.238	0.634	0.294	0.832	0.532	0.041	0.971	1.456	0.426	2.101	0.047
OXTR	rs7632287 A/G	additive	-0.013	0.980	0.199	0.728	-0.544	0.588	0.030	0.973	0.027	0.981	-1.177	0.180
	rs2254298 A/G	additive	-0.808	0.273	-1.016	0.226	0.290	0.850	-1.192	0.378	-0.855	0.530	0.016	0.989
	rs53576 A/G	additive	-0.053	0.894	0.189	0.675	-0.875	0.305	-0.141	0.853	0.411	0.522	0.950	0.146
	rs2228485 C/T	dominant	-0.679	0.258	-0.081	0.905	-2.684	0.035	-0.834	0.444	-0.243	0.800	-2.411	0.019
	rs237911 G/A	domdev	0.498	0.427	0.459	0.465	-2.055	0.131	3.419	0.085	0.224	0.882	-2.141	0.048
HTR2A	rs7322347 A/T	additive	0.741	0.094	0.779	0.105	0.588	0.602	0.257	0.746	0.995	0.199	0.475	0.550
SLC6A4	rs4795541 L/S	recessive	0.520	0.441	-0.199	0.790	3.798	0.009	1.358	0.298	0.066	0.958	-0.312	0.792
	rs1042173 T/	additive	-0.069	0.863	-0.023	0.957	0.588	0.602	-0.218	0.767	0.308	0.662	-0.734	0.248

^∗Sex, ethnicity and age were included as covariates in linear regression models.

^aSNP model (additive, dominant, recessive, or dominance deviation from additivity) best explaining variance in depression score (based on AIC criterion) is reported. In the case of non-significant association between SNP and depression level in any examined group the values for additive model are shown.

^bP_FDR = 0.047. domdev - dominance deviation from additivity model (A1A2 vs A1A1+A2A2). MiA/MaA – Minor allele/major allele. Statistically significant P-values after FDR correction are marked in bold.