Table 5.
Significant multiple linear regression models (with GxE interaction) explaining variation in depression score controlled for sex and ethnicity.
| Items in linear regression model | Ref. group | Model 1 |
Model 2 |
Model 3 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | T | P | β | T | P | β | T | P | ||
| rs1042173 (SLC6A4) | T-allele | -0.16 | -0.08 | 0.936 | -0.72 | -1.12 | 0.263 | 1.00 | 0.37 | 0.710 |
| Sex | Women | 1.33 | 1.12 | 0.263 | 2.23 | 2.4 | 0.015 | 2.20 | 1.46 | 0.143 |
| Ethnicity | Russians | -0.41 | -0.37 | 0.706 | -1.65 | -1.60 | 0.109 | -1.15 | -0.62 | 0.530 |
| Tatars | -1.79 | -1.56 | 0.119 | -4.07 | -4.20 | <0.001 | -1.85 | -1.11 | 0.266 | |
| rs1042173 x sex | T∗women | 0.11 | 0.10 | 0.915 | - | - | - | -0.13 | -0.10 | 0.916 |
| rs1042173 x ethnicity | Russians | 0.17 | 0.18 | 0.855 | - | - | - | -0.68 | -0.40 | 0.683 |
| Tatars | -0.71 | -0.68 | 0.491 | - | - | - | -2.57 | -1.66 | 0.097 | |
| Sibship size | ≥3 | - | - | - | -3.01 | -2.17 | 0.030 | -2.76 | -1.90 | 0.057 |
| rs1042173 x sibship size | T∗≥3 | - | - | - | 2.89 | 2.39 | 0.017 | 2.66 | 2.05 | 0.040 |
| rs53576 (OXTR) | A-allele | -2.68 | -1.42 | 0.154 | 4.33 | 2.52 | 0.012 | 2.27 | 0.79 | 0.431 |
| Sex | Women | 0.28 | 0.23 | 0.815 | 1.05 | 1.10 | 0.270 | 0.28 | 0.18 | 0.855 |
| Ethnicity | Russians | -0.71 | -0.66 | 0.508 | -0.11 | -0.12 | 0.904 | -1.27 | -0.86 | 0.392 |
| Tatars | -3.97 | -3.18 | 0.001 | -3.13 | -3.35 | <0.001 | 1.09 | 0.84 | 0.404 | |
| rs53576 x sex | A∗women | 1.17 | 1.18 | 0.234 | - | - | - | 0.72 | 0.57 | 0.571 |
| rs53576 x ethnicity | Russians | 0.35 | 0.37 | 0.708 | - | - | - | 1.21 | 0.91 | 0.362 |
| Tatars | 1.53 | 1.48 | 0.139 | - | - | - | 1.09 | 0.83 | 0.404 | |
| Paternal care | High | - | - | - | 0.29 | 0.23 | 0.810 | 0.25 | 0.20 | 0.841 |
| rs53576 x paternal care | A∗high | - | - | - | -2.52 | -2.38 | 0.017 | -2.49 | -2.33 | 0.020 |
| rs237911 (OXTR) | G-allele | -3.45 | -1.55 | 0.121 | 0.55 | 0.79 | 0.427 | -1.99 | -0.78 | 0.435 |
| Sex | Women | 0.63 | 0.73 | 0.466 | 1.25 | 1.60 | 0.108 | 0.56 | 0.60 | 0.547 |
| Ethnicity | Russians | -0.62 | -0.80 | 0.423 | -0.06 | -0.09 | 0.925 | 0.12 | 0.14 | 0.886 |
| Tatars | -2.27 | -1.59 | 0.112 | -2.67 | -3.48 | <0.001 | -1.88 | -2.18 | 0.030 | |
| rs237911 x sex | G∗women | 2.18 | 1.73 | 0.084 | - | - | - | 2.04 | 1.46 | 0.144 |
| rs237911 x ethnicity | Russians | 0.83 | 0.68 | 0.494 | - | - | - | -0.87 | -0.63 | 0.526 |
| Tatars | -2.27 | -1.59 | 0.112 | - | - | - | -2.78 | -1.87 | 0.062 | |
| OB | 2 | - | - | - | 1.59 | 2.02 | 0.043 | 1.59 | 2.03 | 0.042 |
| rs237911 x OB | G∗2 | - | - | - | -2.74 | -2.15 | 0.031 | -2.71 | -2.12 | 0.035 |
| rs33911258 (AVPR1В) | G-allele | 0.80 | 0.28 | 0.778 | 0.16 | 0.26 | 0.790 | 0.82 | 0.27 | 0.789 |
| Sex | Women | 1.58 | 1.77 | 0.075 | 1.59 | 2.09 | 0.036 | 1.78 | 1.89 | 0.058 |
| Ethnicity | Russians | -0.13 | -0.16 | 0.866 | -0.36 | -0.51 | 0.603 | -0.37 | -0.44 | 0.659 |
| Tatars | -2.74 | -3.16 | 0.002 | -2.26 | -3.01 | 0.002 | -2.80 | -3.18 | 0.001 | |
| rs33911258 x sex | G∗women | -0.41 | -0.28 | 0.777 | - | - | - | -0.62 | -0.39 | 0.692 |
| rs33911258 x ethnicity | Russians | -0.27 | -0.22 | 0.823 | - | - | - | 0.06 | 0.04 | 0.961 |
| Tatars | 1.04 | 0.71 | 0.477 | - | - | - | 1.87 | 1.21 | 0.225 | |
| Smoking | Previous | - | - | - | 0.48 | 0.40 | 0.689 | 0.47 | 0.38 | 0.701 |
| rs33911258∗smoking | G∗previous | - | - | - | 5.87 | 2.70 | 0.007 | 6.13 | 2.78 | 0.005 |
Additive effect of SNPs on depression score is shown while controlled for sex and ethnicity (Models 1, 2, 3). Smoking – previous smoking. OB – order of birth. Ref. group – reference group. Statistically significant P-values after FDR-correction for GxE interaction are shown in bold. Ethnicity was encoded as a set of dummy variables for the inclusion in the models. The number of children higher than three in the family is included in the model. Previous smoking is included in the model.