3.

Univariate and multivariate linear analysis using age as a continuous variable, adjusting for baseline differences between young and older patients (hypertension, smoking, multivessel disease, LDL-C, TG, TC, NT-pro-BNP and baseline medication) and sex. ΔIPAQ, Δpro-BNP and C reactive protein were log-transformed

	Univariate analysis			Multivariate analysis
	B coefficient	CI		B coefficient	CI
*Statistically significant. BMI: body mass index; CRP: cardiac rehabilitation program; HbA1c: glycated haemoglobin; HDL-C: high-density lipoprotein cholesterol; IPAQ: International Physical Activity Questionnaire; LDL-C: low-density lipoprotein cholesterol; METs: metabolic equivalents; NT-pro-BNP: NT pro-brain natriuretic peptide; TC: total cholesterol; TG: triglycerides.
ΔFunctional capacity (METs)	0.003	-0.002-0.01		0.01	-0.0005-0.02
ΔIPAQ	-0.02	-0.007--0.02		-0.01	-0.02--0.01 *
ΔBMI, Kg/m2	0.006	-0.22-0.9		0.001	-0.01-0.01
ΔAbdominal perimeter, cm	-0.006	-0.03-0.02		0.02	-0.02-0.06
ΔTotal cholesterol, mg/dL	1.00	0.78-1.20		0.81	-0.13-1.74
ΔHDL-C, mg/dL	0.002	-0.05-0.05		0.02	-0.08-0.13
ΔLDL-C, mg/dL	0.82	0.65-1.00		0.25	-0.03-0.54
ΔTriglycerides, mg/dL	0.86	0.48-1.24		0.07	-0.61-0.47
ΔHbA1c, %	0.006	0.001-0.01		0.01	0.002-0.02 *
ΔNT-pro-BNP, ng/mL	0.006	-0.03-0.04		0.18	-0.18-0.04
C reactive protein, mg/dL	-0.02	-0.07-0.04		-0.08	-0.27-0.10