Table 1.
Patient Demographics
| Overall Cohort: Hyporesponder (N = 43,316) | Overall Cohort: Normoresponder (N = 67,403) | P | |
|---|---|---|---|
| Demographics on index date | |||
| Age as of index date, y | 62.3 ± 15.2 | 63.6 ± 14.4 | <0.001a |
| Female | 24,272 (56.0) | 33,194 (49.2) | <0.001a |
| Race | <0.001a | ||
| Black | 17,979 (41.5) | 25,022 (37.1) | |
| White | 22,225 (51.3) | 38,242 (56.7) | |
| Other/unknown | 3,112 (7.2) | 4,139 (6.1) | |
| Weight on index date, kg | 73.0 ± 20.2 | 83.4 ± 23.9 | <0.001a |
| Comorbid conditions during baseline period | |||
| Charlson Comorbidity Index score | 3.8 ± 2.2 | 3.2 ± 2.0 | <0.001a |
| Hypertension | 38,151 (88.1) | 54,544 (80.9) | <0.001a |
| Type 2 diabetes | 22,462 (51.9) | 36,277 (53.8) | <0.001a |
| Hyperlipidemia | 22,092 (51.0) | 32,365 (48.0) | <0.001a |
| Heart failure | 20,777 (48.0) | 24,412 (36.2) | <0.001a |
| Coronary heart/artery disease | 18,071 (41.7) | 23,643 (35.1) | <0.001a |
| Arrhythmia | 14,121 (32.6) | 17,064 (25.3) | <0.001a |
| Type 1 diabetes | 5,124 (11.8) | 7,855 (11.7) | 0.38 |
| Valvular heart disease | 1,305 (3.0) | 1,200 (1.8) | <0.001a |
| Cardiovascular event–related hospitalizations during baseline period | |||
| Hospitalization related to heart failure | 2,308 (5.3) | 1,931 (2.9) | <0.001a |
| Hospitalization related to thromboembolic event | 396 (0.9) | 219 (0.3) | <0.001a |
| Hospitalization related to stroke | 232 (0.5) | 205 (0.3) | <0.001a |
| Hospitalization related to myocardial infarction | 318 (0.7) | 270 (0.4) | <0.001a |
Note: Data for categorical variables expressed as number (percent); data for continuous variables expressed as mean ± standard deviation.
a
Statistically significant.