Table 2.
Brain regions in resting-state networks (RSNs) with significant differences in functional connectivity among FOG+, FOG-, and HC participants.
| RSNs/regions (AAL) | Cluster size (mm3) | Peak MNI coordinates (x y z) | Peak T-value | ||
|---|---|---|---|---|---|
| X | Y | Z | |||
| AUN | |||||
| TPS.L | 104 | -45 | 3 | -15 | 24.1194 |
| PreCG.R | 45 | 54 | 3 | 27 | 30.5567 |
| MCG.R | 96 | 6 | 30 | 33 | 29.8302 |
| DMN | |||||
| SFGmed.L | 21 | -3 | 66 | 6 | 30.5884 |
| PCUN.L | 1297 | 6 | -63 | 36 | 97.2039 |
| ANG.L | 95 | -48 | -57 | 27 | 42.8589 |
| ANG.R | 109 | 51 | -54 | 36 | 28.296 |
| DAN | |||||
| ITG.R | 56 | 51 | -60 | -9 | 23.913 |
| PCUN.R | 64 | 15 | -57 | 15 | 45.5962 |
| IFGoperc.R | 182 | 57 | 9 | 27 | 62.9567 |
| SMG.R | 1117 | 42 | -27 | 42 | 69.4657 |
| PCUN.L | 2853 | 3 | -63 | 54 | 175.8931 |
| LFPN | |||||
| ITG.L | 20 | -66 | -48 | -12 | 84.2057 |
| ORBmid.L | 20 | -33 | 57 | -12 | 41.5616 |
| RFPN | |||||
| MFG.R | 27 | 33 | 21 | 51 | 21.3332 |
| SMN | |||||
| SMA.L | 152 | 3 | 3 | 72 | 24.0919 |
| VIN | |||||
| MOG.R | 631 | 39 | -90 | 3 | 65.4637 |
| MOG.L | 817 | -27 | -99 | 9 | 66.4165 |
The T-value was obtained by post hoc analysis of one-sample t-tests, corrected pFWE < 0.01, cluster extent threshold of 20 voxels. FOG+/FOG-: Parkinson's disease with/without freezing of gait; HC: healthy controls; MNI: Montreal Neurological Institute; L/R: left/right hemisphere; AUN: auditory network; TPS: temporal pole: superior temporal gyrus; PreCG: precentral gyrus; MCG: median cingulate and paracingulate gyrus; DMN: default mode network; SFGmed: superior frontal gyrus, medial; PCUN: precuneus; ANG: angular gyrus; DAN: dorsal attention network; ITG: inferior temporal gyrus; IFGoperc: inferior frontal gyrus, opercular part; SMG: supramarginal gyrus; LFPN: left frontoparietal network; ORBmid: middle frontal gyrus, orbital part; RFPN: right frontoparietal network; MFG: middle frontal gyrus; SMN: somatomotor network; SMA: supplementary motor area; VIN: visual network; MOG: middle occipital gyrus.