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. 2020 Oct 8;2020:4581954. doi: 10.1155/2020/4581954

Figure 4.

Figure 4

GSEA of the whole mRNA expression profiling data. We use the GO terms, KEGG pathway, and REACTOME pathway as predefined gene sets. Gene sets with FDR < 0.05 were considered significantly enriched. (a) Significantly enriched gene sets relating to GO terms in GSEA. (b) Significantly enriched gene sets relating to the KEGG and REACTOME pathways in GSEA. NES: normalized enrichment score. Generally, the greater absolute value of NES means that the expressions of genes in the gene set are more accordantly changed in experimental conditions. The positive NES value indicates higher expression of gene sets in the normal group. The negative NES value indicates higher expression of gene sets in the diabetic group.