Table 1.
Baseline characteristics of the studies included in the meta-analysis.
| Study (year) | Nation | Study design | Period | Study database | Age (y), average (range or SD) | Menopausal status | No. of cases | No. of participants | Prevalence of breast cancer (%) |
|---|---|---|---|---|---|---|---|---|---|
| Cardwell (2011) [6] | UK | Cohort | 1996-2006 | GPRD | 70 (11.4) | Pre- & post- | 870 | 68098 | 1.28% |
| Chiang (2012) [7] | Taiwan | Cohort | 1998-2009 | NHIRD | 73.5 (8.4) | Post- | 209 | 27903 | 0.75% |
| Chlebowski (2010) [8] | USA | Cohort | 1993-1998 | WHI | NA (50-79) | Post- | 6276 | 154768 | 4.06% |
| Fournier (2017) [9] | France | Cohort | 2004-2011 | E3N | 62.8 (6.4) | Post- | 2407 | 64438 | 3.73% |
| Hue (2014) [10] | USA | Cohort | 1993-2006 | FIT & HORIZON-PFT | 70.6 (5.8) | Post- | 165 | 13774 | 1.2% |
| Lee (2012) [11] | Taiwan | Cohort | 1996-2009 | NHI | NA (≥65) | Pre- & post- | 65 | 18499 | 0.35% |
| Monsees (2011) [12] | USA | Case-control | 1990-2007 | SEER | NA (40-79) | Pre- & post- | 351 | 1013 | NA |
| Newcomb (2010) [13] | USA | Case-control | 2003-2006 | WMCR | 54.2 (8.9) | Pre- & post- | 2936 | 5911 | NA |
| Rennert (2010) [14] | Israel | Case-control | 2000-2006 | CHS | 63.6 (NA) | Post- | 1832 | 4039 | NA |
| Vestergaard (2011) [16] | Denmark | Cohort | 1996-2006 | DPB | 71.1 (10.7) | Pre- & post- | 4349 | 342651 | 1.27% |
| Vinogradova (2013) [15] | UK | Case-control | 1997-2011 | QResearch & CPRD | 69.4 (9.8) | Pre- & post- | 49933 | 282713 | NA |
Abbreviations: CHS: Clalit Health Service; CPRD: Clinical Practice Research Datalink; SEER: Surveillance, Epidemiology, and End Results; WMCR: Wisconsin Mandatory Cancer Registry; DPB: Danish population base; GPRD: General Practice Research Database; NHIRD: National Health Insurance Research Database; WHI: Women's Health Initiative; E3N: Etude Epidémiologique Auprès de Femmes de la Mutuelle Générale de l'Education Nationale; FIT: Fracture Intervention Trial; HORIZON-PFT: Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly-Pivotal Fracture Trial; NHI: National Health Insurance; NA: not available; SD: standard deviation.