Vincristine down-regulates cellular and exosomal miR-181a expression in the first time diagnosed leukemia B cells. JM1, Sup-B15, and NALM-6 cells were treated with vincristine (4.0 µM) for 24 h. A. Cellular miR-181a expression was quantified by qPCR, and results were displayed in fold change. B. Exosomal miR-181a expression was quantified by qPCR and results were displayed in fold change. SNORD61 was used as an endogenous control. (P-value *p<0.05, **p<0.01, ***p<0.001).