Table 2.
The chemicals produced by MG1655 or MG1655 derivatives.
| Chemicals | Titer (g/L) | Approach | Reference | |
|---|---|---|---|---|
| Acid | Succinic acid | 42.5 | Deletion of pflB and ldhA. Overexpression of PEP carboxykinase. | [63] |
| Itaconic acid | 47 | Using temperature-sensitive promoter to control the TCA cycle dynamically | [64] | |
| Citramalic acid | 46.5 | Deletion of citrate synthase and acetate kinase | [65] | |
| Fatty acid | 82.64 (mg/g) | Overexpression of accA, accB, accC, fabD, and EC 3.1.2.14 gene | [66] | |
| Amino acid | l-serine | 11.7 | Deletion of three l-serine deaminases (gene sdaA, sdaB, and tdcG) and serine hydroxyl methyl transferase (gene glyA). Overexpression of eamA | [67] |
| Alcohol | 1,4-butanediol | 110 | Containing Cat2 variants with improved BDO tolerance and Ald variant with improved in vitro activity, expression, and stability | [68] |
| 1,2-Propanediol | 5.6 | Overexpression of mgsA, gldA, and yqhD. Replacing the native PEP-dependent dihydroxyacetone kinase (DHAK) with an ATP-dependent DHAK. Disrupting the lactate and acetate synthesis pathway. | [69] | |
| Ethylene glycol | 20 | Deletion of xylB, aldA. Overexpressing fucO | [70] | |
| Terpenoid | Taxadiene | 1 | Separating the taxadiene metabolic pathway into two modules | [71] |
| Aldehyde | Vanillin | 0.119 | Deletion of native aldehyde reductases and expression of key enzymes for converting 3-dehydroshikimiate to vanillin | [72] |
| Ester | 2-phenylethl acetate | 0.268 | Combined the synthesis pathway of 2-phenylethanol and 2-phenylethylacetate by overexpressing an alcohol acetyltransferase ATF1 | [73] |