Table 1:
Comparison of cytomorphological features in G1, G2, and G3-WD Pan NETs and G3-PD Pan NEC.
| Cytological features | WD-Pan NET | PD-Pan NEC | ||
|---|---|---|---|---|
| G1 (n=19) | G2 (n=8) | G3-WD (n=2) | G3-PD (n=3) | |
| Ki-67 index range | 1–<3% | 3–10% | 21–27% | 29–90% |
| Architecture | ||||
| Perivascular arrangement of tumor cells | 6 | 2 | 1 | 0 |
| Rosettes | 9 | 2 | 2 | 2 |
| Molding | 5 | 3 | 1 | 2 |
| Plasmacytoid | 15 | 6 | 1 | 1 |
| Nuclear features | ||||
| Shape | Round (17) Angulated (2) | Round (6) Angulated (2) | Round (1) Angulated (1) | Round (1) Angulated (3) |
| Smooth nuclear contour | 18 | 7 | 2 | 2 |
| Chromatin (salt and pepper) | 16 | 4 | 1 | 1 |
| Nuclear tangles | 4 | 3 | 1 | 3 |
| Prominent nucleoli | 1 | 2 | 1 | 2 |
| Nuclear pleomorphism | 2 | 2 | 1 | 2 |
| Cytoplasm | ||||
| Abundant cytoplasm | 14 | 5 | 1 | 0 |
| Background | ||||
| Apoptosis | 2 | 4 | 1 | 3 |
| Necrosis | 0 | 2 | 1 | 2 |
WD: Well differentiated, PD: Poorly differentiated