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. 2020 Sep 28;117(41):25254–25262. doi: 10.1073/pnas.2010722117

Fig. 6.

Fig. 6.

Skewing of TRBV usage in severe/hyperinflammatory COVID-19 patients; 24 repertoires of severe/hyperinflammatory COVID-19 cases versus 42 repertoires of mild/moderate COVID-19 cases were analyzed with and without 23 repertoires of age-matched healthy donors (age-matched to severe/hyperinflammatory COVID-19 group). (A) PCA of TRBV usage. Principal components 1 and 2 are shown; percentage of axis contributions are given in parentheses. Statistical analysis was performed using multivariate analysis of variance (MANOVA) Pillai–Bartlett test. (B) TRBV usage. The fraction of individual TRBV genes per repertoire is shown as mean ± SEM. TRBV genes are sorted to enriched fractions in severe/hyperinflammatory versus mild/moderate COVID-19 disease in ascending order from bottom to top. The top TRBVs enriched in severe/hyperinflammatory COVID-19 patients (TRBV5-6, TRBV14, TRBV13, and TRBV24-1) are enlarged in Inset. (C) PCA of TRBJ usage as described in A. See also SI Appendix, Fig. S7.