Table 1.

Similarities between clinical and laboratory features of MIS-C and pediatric TSS

Clinical Features	MIS-C*	Pediatric TSS†
High fever	+	+
Skin rash	+	+
Conjunctivitis	+	+
Oral mucosal involvement	+	+
Myalgia	+	+
Hypotension	+	+
Myocardial involvement (dysfunction)	+	+
Gastro-intestinal symptoms (vomiting, diarrhea, abdominal pain)	+	+
Renal involvement	+	+
CNS symptoms, altered mental state	+	+
Headache	+	+
High C-reactive protein (CRP)	+	+
High ferritin	+	+
High IL-6	+	+
High D-dimers	+	+
High procalcitonin	+	+
Lymphopenia	+	+
Reduced platelet count	+	+
Increased neutrophil count	+	+
Increased aspartate amino transferase (AST) and alanine transaminase (ALT)	+	+
High pro b-type natriuretic peptide (pro-BNP)	+	NA
High troponin	+	NA
Isolation of TSS inducing bacteria (Staphylococcus or Streptococcus)	–	+

NA, not available; + represents association with reported cases; –, no association.

^*Taken from refs. 5 to 7.

^†Taken from refs. 8, 9, 61, and 62.