Fig. 2.

Distinct proteome profiles of BEAS-2B cells exposed to NSOA upon atmospheric aging. (A) Scatter plot and box plot showing the distribution of log₂ expression fold change (FC) values of proteins detected in different exposure groups compared to vehicle control (0.1% DMSO); proteins with values of P < 0.05 are shown. FC > 1.5 was used as cutoff for significance in protein expression. Red, green, and gray dots indicate up-regulated proteins, down-regulated proteins, and not significantly changed proteins, respectively (B). UpSet plot showing overlap in significantly regulated proteins identified in different exposure groups. Each column of the top bar plot corresponds to an interaction that is containing the groups indicated by solid dots below. Total regulated proteins in different groups are represented by the left bar plot as “set size.”