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. 2020 Sep 24;117(41):25818–25829. doi: 10.1073/pnas.2006138117

Fig. 6.

Fig. 6.

S1PR2 activation is necessary for exploration-induced survival of adult-born DGCs. (A) E/I ratio in shS1PR2- and shCtrl-injected mice in HC and EE conditions. (B) Relationship between the number of new DGCs/d and E/I ratio; ρ was 1.6 based on the recordings depicted in Fig. 5 C–F. Inset plot shows the predicted number of newborn DGCs in shS1PR2- and shCtrl-injected mice. (C) Schematic diagram showing the experimental design. (D and E) Representative images of BrdU labeling and (D) and quantification of surviving new DGCs (n.s., P > 0.05; *P < 0.05; unpaired t test) Scale bar, 50 μm. (E). (F, Left), verification that BrdU+ cells are DCX+; (Right) quantification of BrdU and DCX coexpression in the dentate gyrus. Scale bar, 10 μm. (G, Left) Representative images of DCX+ cells; (Right) quantification of immature DGCs (n.s., P > 0.05; *P < 0.05; unpaired t test). Scale bar, 20 μm.