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. 2020 Oct 17;18:144. doi: 10.1186/s12951-020-00707-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — a DNA dissociation profile of the LOrn1/DNA and LOrn3/DNA lipoplexes, evaluated by gel electrophoresis at a pH of 5.5; the lipoplexes were measured at a pH of 7.0 as controls. b Quantitative analysis of accumulative DNA release by gel electrophoresis. Significance levels: *p < 0.05, **p < 0.01. c Intracellular release of DNA in HeLa cells as determined by LSCM. White arrows showed the aggregation state of FAM-labeled DNA. d Co-localization ratio of FAM-DNA (green) and lysosomes (red). 8–10 Cells in each group were selected randomly. Significance levels: *p < 0.05 vs. 12 h, **p < 0.01 vs. 12 h. e Fluorescence spectra of Rhodamine 123 in HeLa cell lysates with culture times of 2, 4, 6, 8, 12, 24, 36, and 48 h after transfection with LOrn3/DNA lipoplex