Table 2.
Carbapenemase genes, MHT, mCIM, eCIM, and antibiotic susceptibility of 195 CRE isolates
| Species | Carbapenemase-encoding genesa | No. of strains | MHT (n) | mCIM (n) | eCIM (n) | Carbapenem resistance (n)b | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neg | Pos | Neg | Pos | Neg | Pos | IPM | ETP | MEM | DOP | |||
| Citrobacter koseri | blaOXA-48 | 4 | 0 | 4 | 0 | 4 | 4 | 0 | 4 | 4 | 4 | 4 |
| None | 3 | 3 | 0 | 3 | 0 | ND | ND | 2 | 3 | 2 | 2 | |
| Enterobacter cloacae | blaIMP | 2 | 1 | 1 | 0 | 2 | 0 | 2 | 2 | 2 | 2 | 2 |
| blaOXA-48 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | |
| None | 9 | 9 | 0 | 9 | 0 | ND | ND | 4 | 9 | 2 | 3 | |
| Escherichia coli | blaKPC | 5 | 0 | 5 | 0 | 5 | 5 | 0 | 5 | 5 | 5 | 5 |
| blaNDM | 11 | 6 | 5 | 0 | 11 | 0 | 11 | 11 | 11 | 11 | 11 | |
| blaOXA-48 | 13 | 1 | 12 | 0 | 13 | 12 | 1 | 10 | 13 | 10 | 11 | |
| blaNDM/blaOXA-48 | 3 | 1 | 2 | 0 | 3 | 2 | 1 | 3 | 3 | 3 | 3 | |
| None | 18 | 18 | 0 | 18 | 0 | ND | ND | 10 | 16 | 6 | 5 | |
| Klebsiella aerogenes | blaVIM | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
| blaNDM | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | |
| None | 6 | 5 | 1 | 6 | 0 | ND | ND | 5 | 6 | 3 | 2 | |
| Klebsiella pneumoniae | blaKPC | 29 | 0 | 29 | 0 | 29 | 29 | 0 | 29 | 29 | 29 | 29 |
| blaIMP | 5 | 2 | 3 | 0 | 5 | 1 | 4 | 5 | 5 | 4 | 4 | |
| blaVIM | 2 | 1 | 1 | 0 | 2 | 0 | 2 | 2 | 2 | 2 | 2 | |
| blaNDM | 3 | 2 | 1 | 0 | 3 | 0 | 3 | 3 | 3 | 3 | 3 | |
| blaOXA-48 | 23 | 1 | 22 | 0 | 23c | 23 | 0 | 22 | 23 | 22 | 21 | |
| blaKPC/blaOXA-48 | 2 | 0 | 2 | 0 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | |
| None | 54 | 53 | 1 | 54 | 0 | ND | ND | 28 | 54 | 25 | 23 | |
| Total | 195 | 10 | 91 | 90 | 105 | 79 | 26 | 149 | 193 | 138 | 134 | |
aClass A carbapenemase, KPC; Class B carbapenemase, IMP, NDM, and VIM; Class D carbapenemase, OXA-48
bAntibiotic susceptibility to carbapenems was determined by disc diffusion. IPM, imipenem; ETP, ertapenem; MEM, meropenem; DOP, doripenem
cThe results of 2 mCIM tests were interpreted as “indeterminate” (pinpoint colonies were present within a 16- to 18-mm zone)
Pos positive, Neg negative