Table 1.
Integrative genomics analysis highlighted 11 highlighted genes contributed to moderate-to-severe asthma risk
| Gene name | Simulated P-value (Sherlock analysis of Dataset #3) | Simulated P-value (Sherlock analysis of Dataset #4) | Simulated P-value (Sherlock analysis of Dataset #5) | MAGMA-based P-value (Dataset #1) |
MAGMA-based P value (Dataset #2, negative control) | GWAS Catalog documented genes |
|---|---|---|---|---|---|---|
| HLA-DRB5 | 7.93 × 10−7 | 1.60 × 10−3 | 4.09 × 10−6 | 7.57 × 10−10 | 0.11 | Documented gene |
| HLA-DRB1 | 7.93 × 10−7 | 4.64 × 10−6 | 4.09 × 10− 6 | 1.41 × 10−11 | 0.59 | Documented gene |
| GNGT2 | 1.11 × 10−5 | 2.30 × 10−4 | 1.83 × 10−2 | 1.42 × 10− 2 | 0.48 | Documented gene |
| HLA-DQA1 | 2.85 × 10−5 | 7.73 × 10−7 | 1.49 × 10−3 | 2.90 × 10−23 | 0.58 | Documented gene |
| SLC22A5 | 1.85 × 10−4 | 3.87 × 10−5 | 2.66 × 10− 5 | 1.23 × 10−6 | 0.46 | Documented gene |
| STAT6 | 2.19 × 10−4 | 2.75 × 10−2 | 3.31 × 10− 2 | 1.94 × 10−11 | 0.97 | Documented gene |
| MPI | 1.90 × 10−3 | 2.02 × 10−2 | 2.39 × 10−2 | 1.12 × 10−5 | 0.84 | Not documented gene |
| TLR6 | 3.63 × 10−3 | 3.54 × 10− 3 | 6.69 × 10− 3 | 4.10 × 10−2 | 0.93 | Documented gene |
| DECR2 | 1.62 × 10−2 | 4.32 × 10− 2 | 1.58 × 10−4 | 2.22 × 10− 2 | 0.78 | Not documented gene |
| LNPEP | 2.28 × 10−2 | 5.55 × 10−4 | 4.33 × 10−2 | 3.98 × 10− 2 | 0.46 | Not documented gene |
| TTC19 | 2.52 × 10−2 | 1.81 × 10−2 | 2.20 × 10− 2 | 3.23 × 10− 2 | 0.30 | Not documented gene |