Fig. 4.

Susceptible and resilient subgrouping as determined by elevated zero maze reflects peripheral inflammatory alterations. Mice were run through the 10-day RSDS paradigm followed by behavioral testing and plasma extraction. Both RSDS and control mice were categorized into susceptible or resilient groups by elevated zero maze (EZM; normalized distance moved + normlaized time in open) < median, or > median, respectively. Circulating levels of 29 cytokines were assessed by Meso Scale Discovery multiplex analysis; 26 were above the limit of detection, and 8 showed significant differences between control and RSDS animals. N = 35 control, 40 RSDS. Statistical significance by parametric Student’s t-test or nonparametric Mann-Whitney U test.