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. 2020 Oct 16;10:17589. doi: 10.1038/s41598-020-74613-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Oligomycin A treatment upregulates dendritic mitochondrial fragmentation and reduces spinal mitochondrial distribution in cultured hippocampal neuron. (a) Dendritic mitochondrial density of cultured hippocampal neurons with vehicle or 1 µM oligomycin A treatment. Unpaired student’s t-test; ***P < 0.001. n = 20 dendritic segments. (b1) Dendritic mitochondrial length of cultured hippocampal neurons with vehicle or 1 µM oligomycin A treatment. Unpaired student’s t-test; ***P < 0.001. n = 92 and 132 mitochondria, respectively. (b2) The corresponding cumulative curve of (b1). (c) The ratio of mitochondria-containing dendritic spines in cultured hippocampal neurons with vehicle or 1 µM oligomycin A treatment. Unpaired student’s t-test; *P < 0.05. n = 25–30 dendritic segments. (d) Representative images of dendritic spines (green) and mitochondria (red). Scale bar 5 µm.