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. 2020 Oct 16;10:17593. doi: 10.1038/s41598-020-74617-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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mRNA expression levels of the lipid metabolism-related genes increased by HFD were decreased in FD-KO mice. (a) Relative mRNA expression levels of the genes related to fatty acid uptake (Pparγ2, Cd36, and Fatp2), and (b) de novo lipogenesis (Srebp-1c, Fasn, and Scd1) in liver of WT mice or FD-KO mice fed with NC or HFD for 17 weeks. N = 7, 6, 7, 9. *p < 0.05, **p < 0.01, ***p < 0.001, **** p < 0.0001 by one-way ANOVA followed by a Tukey's post-hoc test.