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. 2020 Oct 16;11(10):871. doi: 10.1038/s41419-020-03080-x

Fig. 6. PVT1 promoted miR-18b-5p DNA promoter methylation by recruiting DNMT1 via EZH2.

Fig. 6

A The subcellular location of PVT1 in GBC-SD and SGC-996 cells. B ChIP-qRT-PCR analysis of DNMT1 occupancy at the miR-18b-5p promoter regions in GBC-SD and SGC-996 cells. C Relative RIP assays detecting the binding of PVT1 with EZH2 in GBC-SD and SGC-996 cells by qRT-PCR. D The interaction between DNMT1 and EZH2 in GBC-SD and SGC-996 cells when PVT1 was overexpressed or knockdown validated by Co-IP assays. **p < 0.01, ***p < 0.001.