Table 1.
Trends in papillary thyroid carcinoma incidence rates (2000-2017): Surveillance, Epidemiology, and End Results–18 Registry Databasea
| Age-standardized rate, per 100 000 | Segment 1 | Segment 2 | Segment 3 | Segment 4 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 2000 | 2017 | Years | APC (95% CI) | Years | APC (95% CI) | Years | APC (95% CI) | Years | APC (95% CI) | |
| Total PTC, cm (n = 163 387) | 6.10 | 12.15 | 2000-2009 | 7.33 (6.92 to 7.75) | 2009-2012 | 3.69 (0.22 to 7.28) | 2012-2015 | 1.39 (–1.82 to 4.71) | 2015-2017 | –4.55 (–7.62 to –1.39) |
| < 1.0 | 1.64 | 3.90 | 2000-2009 | 10.4 (9.46 to 11.3) | 2009-2013 | 3.84 (0.43 to 7.36) | 2013-2017 | –4.33 (–6.33 to –2.29) | ||
| 1.0-1.9 | 1.46 | 3.76 | 2000-2009 | 10.2 (9.48 to 10.8) | 2009-2013 | 3.34 (0.77 to 5.98) | 2013-2017 | –0.52 (–2.03 to 1.02) | ||
| 2.0-3.9 | 1.60 | 2.90 | 2000-2009 | 5.24 (4.60 to 5.89) | 2009-2015 | 2.91 (1.65 to 4.18) | 2015-2017 | –3.42 (–8.43 to 1.87) | ||
| ≥ 4.0 | 0.58 | 1.16 | 2000-2015 | 5.08 (4.58 to 5.58) | 2015-2017 | –7.08 (–15.3 to 1.93) | ||||
| Unknown | 0.81 | 0.40 | 2000-2008 | –8.31 (–11.9 to –4.61) | 2008-2017 | 0.53 (–3.11 to 4.31) | ||||
| Follicular variant of PTC, cm (n = 49 525) | 2.08 | 2.86 | 2000-2006 | 3.29 (1.74 to 4.86) | 2006-2015 | 6.45 (5.63 to 7.28) | 2015-2017 | –21.1 (–26.5 to –15.2) | ||
| < 1.0 | 0.52 | 0.91 | 2000-2015 | 7.19 (6.40 to 7.99) | 2015-2017 | –23.4 (–34.3 to –10.7) | ||||
| 1.0-1.9 | 0.47 | 0.81 | 2000-2014 | 7.59 (6.76 to 8.43) | 2014-2017 | –12.9 (–18.7 to –6.60) | ||||
| 2.0-3.9 | 0.57 | 0.72 | 2000-2002 | 9.10 (–7.24 to 28.3) | 2002-2006 | –0.23 (–7.46 to 7.56) | 2006-2015 | 6.08 (4.62 to 7.57) | 2015-2017 | –21.4 (–31.0 to –10.4) |
| ≥ 4.0 | 0.25 | 0.38 | 2000-2008 | 2.66 (0.32 to 5.06) | 2008-2015 | 7.63 (4.66 to 10.7) | 2015-2017 | –17.0 (–29.4 to –2.28) | ||
| Unknown | 0.26 | 0.04 | 2000-2008 | –16.4 (–22.0 to –10.5) | 2008-2017 | –0.40 (–8.17 to 8.02) | ||||
| Classical variant of PTC, cm (n = 111 058) | 4.01 | 9.04 | 2000-2009 | 8.71 (8.06 to 9.36) | 2009-2017 | 0.98 (0.43 to 1.53) | ||||
| < 1.0 | 1.11 | 2.95 | 2000-2009 | 11.9 (11.3 to 12.6) | 2009-2013 | 0.94 (–1.37 to 3.30) | 2013-2017 | –2.45 (–3.86 to –1.02) | ||
| 1.0-1.9 | 0.99 | 2.88 | 2000-2009 | 11.0 (9.90 to 12.2) | 2009-2017 | 1.67 (0.79 to 2.56) | ||||
| 2.0-3.9 | 1.03 | 2.11 | 2000-2007 | 6.93 (5.27 to 8.62) | 2007-2017 | 2.34 (1.61 to 3.08) | ||||
| ≥ 4.0 | 0.33 | 0.73 | 2000-2009 | 7.12 (5.69 to 8.56) | 2009-2017 | 1.98 (0.75 to 3.22) | ||||
| Unknown | 0.55 | 0.36 | 2000-2017 | –2.25 (–3.50 to –0.99) | ||||||
| Other PTC variants, cm (n = 2804) | NRa | 0.26 | 2000-2017 | 5.92 (3.95 to 7.93) | ||||||
| < 1.0 | NRa | 0.05 | 2000-2017 | 6.23 (3.88 to 8.63) | ||||||
| 1.0-1.9 | NRa | 0.08 | 2000-2014 | 10.8 (7.66 to 14.1) | 2014-2017 | –7.27 (–24.4 to 13.7) | ||||
| 2.0-3.9 | NRa | 0.08 | 2000-2017 | 6.21 (3.88 to 8.60) | ||||||
| ≥ 4.0 | NRa | 0.05 | 2000-2017 | 4.50 (2.34 to 6.70) | ||||||
| Unknown | NRa | NRa | NR | |||||||
Abbreviations: APC, annual percentage change; NR, not reportable; PTC, papillary thyroid carcinoma.
a Rate suppressed; fewer than 16 cases.