Table 4.
Demographics and Clinical Characteristics of CMH+ and CMH− Participants, Based on SGRQ and CAT Definitions at Baseline
| Characteristics, n (%) | Entire Cohort N=1431 | SGRQ | CAT | ||
|---|---|---|---|---|---|
| CMH+ N=639 |
CMH− N=722 |
CMH+ N=686 |
CMH− N=721 |
||
| Age, years | |||||
| 40–49 | 36 (2.5%) | 17 (2.7%) | 18 (2.5%) | 22 (3.2%) | 13 (1.8%) |
| 50–59 | 322 (22.5%) | 190 (29.7%) | 120 (16.6%) | 195 (28.4%) | 116 (16.1%) |
| 60–69 | 587 (41.0%) | 244 (38.2%) | 313 (43.4%) | 260 (37.9%) | 323 (44.8%) |
| 70–79 | 486 (34.0%) | 188 (29.4%) | 271 (37.5%) | 209 (30.5%) | 269 (37.3%) |
| Sex | |||||
| Male | 822 (57.4%) | 383 (59.9%) | 403 (55.8%) | 384 (56.0%) | 428 (59.4%) |
| Female | 609 (42.6%) | 256 (40.1%) | 319 (44.2%) | 302 (44.0%) | 293 (40.6%) |
| Tobacco history | |||||
| Current smoker | 484 (34.4%) | 321 (51.0%) | 138 (19.4%) | 333 (49.5%) | 140 (19.7%) |
| Ex-smoker | 924 (65.6%) | 308 (49.0%) | 574 (80.6%) | 340 (50.5%) | 572 (80.3%) |
| Smoking number pack-years (mean, SD) | 53.9 (43.4) | 53.5 (26.5) | 54.3 (55.3) | 55.5 (55.3) | 52.3 (28.2) |
| FEV1% predicted (mean, SD) | 60.8 (23.0) | 58.1 (21.1) | 62.8 (24.2) | 57.8 (21.0) | 63.8 (24.2) |
| GOLD grade of airflow limitation | |||||
| Grade 1 | 306 (21.4%) | 100 (15.6%) | 187 (25.9%) | 103 (15.0%) | 199 (27.6%) |
| Grade 2 | 640 (44.7%) | 314 (49.1%) | 292 (40.4%) | 337 (49.1%) | 296 (41.1%) |
| Grade 3 | 338 (23.6%) | 155 (24.3%) | 173 (24.0%) | 174 (25.4%) | 155 (21.5%) |
| Grade 4 | 147 (10.3%) | 70 (11.0%) | 70 (9.7%) | 72 (10.5%) | 71 (9.8%) |
| GOLD 2017 Grade | |||||
| A | 325 (24.9%) | 75 (12.7%) | 232 (35.0%) | 45 (7.0%) | 280 (42.0%) |
| B | 728 (55.7%) | 386 (65.4%) | 319 (48.1%) | 438 (68.4%) | 290 (43.5%) |
| C | 22 (1.7%) | 5 (0.8%) | 16 (2.4%) | 2 (0.3%) | 20 (3.0%) |
| D | 231 (17.7%) | 124 (21.0%) | 96 (14.5%) | 155 (24.2%) | 76 (11.4%) |
| BMI | |||||
| <18.5 | 35 (2.5%) | 24 (3.8%) | 11 (1.6%) | 21 (3.1%) | 13 (1.9%) |
| 18.5 to <25 | 457 (32.7%) | 192 (30.8%) | 238 (33.8%) | 226 (33.5%) | 223 (31.9%) |
| 25 to <30 | 479 (34.3%) | 208 (33.3%) | 248 (35.2%) | 219 (32.4%) | 251 (35.9%) |
| ≥30 | 426 (30.5%) | 200 (32.1%) | 208 (29.5%) | 209 (31.0%) | 212 (30.3%) |
| SGRQ Total Score (mean, SD) | 37.7 (19.7) | 44.1 (18.9) | 32.37 (18.6) | 44.87 (18.8) | 30.81 (17.9) |
| CAT Total Score (mean, SD) | 15.3 (7.9) | 18.55 (7.6) | 12.52 (7.1) | 19.71 (6.8) | 11.09 (6.4) |
Abbreviations: BMI, body mass index; CAT, COPD Assessment Test; CMH, chronic mucus hypersecretion; FEV1, forced expiratory volume in one second; GOLD, Global Initiative for Chronic Obstructive Lung Disease; SD, standard deviation; SGRQ, St. George’s Respiratory Questionnaire.