Table 5.

Overall survival between matched MONARCH 1 and real-world chemotherapy cohort

	Monarch 1 N = 108	Real-world cohort N = 108	Difference/p-value
Number of deaths, n (%)	50 (46.3)	79 (73.1)
Patients censored, n (%)	58 (53.7)	29 (26.9)
No documented deaths	58 (53.7)	29 (26.9)
Survival rate, % (95% CI)a
4-month	91.7 (84.6, 95.6)	85.1 (76.9, 90.6)	6.5 (-2.0, 15.0)/p = 0.133
8-month	85.1 (76.9, 90.6)	66.1 (56.2, 74.2)	19.0 (7.8, 30.3)/p = 0.0009
12-month	72.7 (63.2, 80.2)	55.2 (45.1, 64.1)	17.5 (4.8, 30.3)/p = 0.007
24-month	49.1 (38.1, 59.2)	28.5 (19.5, 38.1)	20.6 (6.4, 34.8)/p = 0.004

Overall survival rates were estimated using the Kaplan–Meier method. Corresponding 95% CIs were estimated using the methods of Brookmeyer and Crowley, and Greenwood, respectively

CI Confidence interval, N total number of patients, n number of patients within a specific category

^a95% CIs and 2-sided p-values for the difference between rates were calculated based on normal approximation