Table 3.
Gene expression levels at baseline and treatment effect interaction
| PALOMA-2 | PALOMA-3 | |||||
|---|---|---|---|---|---|---|
| Bone-only (n = 106) |
Nonvisceral (excluding bone-only) (n = 123) |
Visceral (n = 225) |
Bone-only (n = 81) |
Nonvisceral (excluding bone-only) (n = 53) |
Visceral (n = 168) |
|
| Baseline gene mRNA expression levels, median (minimum, maximum) | ||||||
| CDK4 | 10.3 (8.6, 11.2) | 10.2 (8.5, 11.4) | 10.4 (8.3, 11.9) | 11.3 (9.4, 14.2) | 11.4 (10.1, 12.9) | 11.3 (9.7, 13.2) |
| ESR1 | 12.7 (8.6, 16.0) | 13.4 (8.7, 16.0) | 13.1 (7.5, 16.7) | 13.2 (8.8, 16.5) | 12.8 (9.3, 17.3) | 13.4 (8.6, 16.5) |
| CDK6 | 8.7 (6.3, 10.6) | 8.7 (4.2, 10.6) | 8.7 (3.9, 10.5) | 9.9 (8.7, 12.7) | 9.9 (8.8, 12.2) | 9.9 (8.1, 12.1) |
| CCND1 | 12.4 (8.8, 16.7) | 12.7 (8.5, 16.7) | 12.6 (8.6, 16.7) | 13.0 (9.1, 16.5) | 12.9 (8.4, 17.3) | 12.9 (9.0, 17.3) |
| CCND3 | 10.1 (8.2, 11.6) | 10.1 (8.3, 12.2) | 10.1 (8.2, 11.6) | 10.6 (8.1, 12.5) | 10.4 (9.0, 12.0) | 10.3 (8.6, 12.2) |
| CCNE1 | 6.7 (3.7, 9.3) | 6.8 (2.2, 8.7) | 7.0 (3.2, 11.5) | 6.6 (1.9, 9.6) | 7.2 (4.1, 9.7) | 6.9 (1.9, 9.9) |
| Treatment interaction, P value | ||||||
| CDK4 | 0.601 | 0.518 | 0.010 | 0.161 | 0.223 | 0.735 |
| ESR1 | 0.745 | 0.079 | 0.643 | 0.468 | 0.530 | 0.287 |
| CDK6 | 0.718 | 0.526 | 0.338 | 0.008 | 0.818 | 0.654 |
| CCND1 | 0.493 | 0.562 | 0.823 | 0.479 | 0.555 | 0.311 |
| CCND3 | 0.946 | 0.153 | 0.626 | 0.101 | 0.341 | 0.239 |
| CCNE1 | 0.891 | 0.578 | 0.196 | 0.114 | 0.036 | 0.004 |
CCND1 cyclin D1, CCND3 cyclin D3, CCNE1 cyclin E1, CDK4 cyclin-dependent kinase 4, CDK6 cyclin-dependent kinase 6, ESR1 estrogen receptor 1