Figure 2.

Immunological subtypes of gastric cancer. Immunogram analysis of 29 gastric cancer patients was performed. By hierarchical cluster analysis of the immunogram scores, gastric cancer cases were first divided into Immune‐Hot and Immune‐Cold subtypes. Then, Immune‐Hot subtype was further divided into Hot1, Hot2 and Intermediate subtypes. Clinical profiles with histology by the Lauren classification, macroscopic classification by the Borrmann classification, locus of the primary site, TNM clinical staging, overexpression of human epidermal growth factor receptor 2 (HER2) protein and the presence or absence of Helicobacter pylori infection are depicted. EBV, MSI, GS and CIN subtypes of molecular classification by TCGA ⁵ and MSI, MSS/EMT, MSS/TP53⁺ and MSS/TP53⁻ subtypes of ACRG classification ⁶ are indicated by colour. Absolute scores of tumor‐infiltrating cells (TICs) were estimated by CIBERSORTx. ²⁰ Scores for exclusion and dysfunction and signatures for MDSCs, TAM‐M2 and CAF were evaluated by TIDE. ²¹ The EMT subset was determined by a Mesenchymal or Non‐Mesenchymal signature. ¹⁹