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. 2020 Oct 17;17:308. doi: 10.1186/s12974-020-01985-0

Table 2.

Factors associated with cognitive performance

18F-THK-5351 uptake intensity Demographic factors Vascular factors Neurodegenerative factors
Total Z-SUM-2 Total Z-SUM-3 Total Z-SUM-4 Total Z-SUM-5 Age, year Education, year NIHSS Stroke volume, % PVL score DWML score MTA score Cortical thickness, mm
MoCA − 0.26* − 0.29* − 0.28* − 0.22 − 0.42*** 0.59*** − 0.55***† − 0.23† − 0.23 − 0.32*† − 0.11 0.55***†
NPI 0.21 0.21 0.21 0.17 0.08 − 0.16 0.58***† 0.28*† 0.06 0.19 − 0.10 − 0.32†
Depressive symptomsa 0.07 0.05 0.04 0.01 0.06 − 0.11 0.62***† 0.19 0.25 0.22 − 0.06 − 0.24
Anxietyb − 0.10 − 0.13 − 0.13 − 0.13 0.12 − 0.31* 0.28* − 0.10 0.13 − 0.03 0.13 − 0.20
IADL 0.37**† 0.41***† 0.39**† 0.31*† 0.31* − 0.47*** 0.58***† 0.29*† 0.12 0.19 0.03 − 0.44***
IQCODEc 0.42***† 0.42***† 0.37**† 0.29*† 0.34** − 0.25 0.42***† 0.4**† 0.24 0.43***† 0.19 − 0.35**
CDR-SOB 0.31* 0.36**† 0.35**† 0.27*† 0.35** − 0.32** 0.57***† 0.29*† 0.18 0.23 0.03 − 0.45***†
Composite cognitive z score
 General cognitive function − 0.28* − 0.36**† − 0.38**† − 0.34**† − 0.26* 0.51*** − 0.43***† − 0.31*† − 0.24 − 0.29*† − 0.15 0.39**
 Memory function − 0.11 − 0.16 − 0.18 − 0.15 − 0.35** 0.36** − 0.37**† − 0.14 − 0.38**† − 0.27* − 0.18 0.36**
 Visuospatial function − 0.28* − 0.28* − 0.27* − 0.23 − 0.30* 0.21 − 0.25 − 0.24† − 0.09 − 0.26* 0.12† 0.26*
 Executive function − 0.34**† − 0.44***† − 0.45***† − 0.43***† − 0.09 0.39** − 0.41***† − 0.36**† − 0.06 − 0.21 − 0.10 0.32**
 Language function − 0.23 − 0.29*† − 0.32*† − 0.31*† − 0.12 0.66*** − 0.25 − 0.28*† − 0.09 − 0.22† − 0.14 0.24

CDR clinical dementia rating, DWML deep white matter leukoaraiosis, IADL instrumental activities of daily living, IQCODE informant questionnaire on cognitive decline in the elderly, MoCA Montreal cognitive assessment, MTA medial temporal atrophy, NIHSS National Institutes of Health Stroke Scale, NPI neuropsychiatric inventory, PVL periventricular leukoaraiosis, SOB sum of boxes, Z-SUM sum of 18F-THK-5351 uptake intensity Z scores

*P < 0.05; **P < 0.01; ***P < 0.001; †P < 0.05 after adjustment for age and education

aEvaluated by the NPI depression item 4

bEvaluated by the NPI anxiety item 5

CPerformed around 3 months after stroke