Table 2.
Univariate and Multivariate analysis for OS, DFS, and LRFS
| Factor | Univariated |
Multivariated |
Univariated |
Multivariated |
Univariated |
Multivariated |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95%CI) |
P-value | Adjusted HR (95%CI) | P-value | HR (95%CI) |
P-value | Adjusted HR (95%CI) | P-value | HR (95%CI) |
P-value | Adjusted HR (95%CI) | P-value | |
| P16 Status | ||||||||||||
| Positive vs Negative | 0.498 (0.260-0.954) |
0.036 | 0.435 (0.214-0.842) |
0.014 | 0.515 (0.276-0.959) |
0.036 | 0.443 (0.231-0.850) |
0.014 | 0.13 (0.018-0.950) |
0.044 | 0.125 (0.017-0.913) |
0.04 |
| Sex | ||||||||||||
| Female vs Male | 0.731 (0.481-1.110) |
0.142 | 0.686 (0.452-1.039) |
0.075 | 1.019 (0.531-1.955) |
0.956 | ||||||
| ECOG | ||||||||||||
| ≥2 vs 0-1 | 1.973 (1.289-3.019) |
0.002 | 2.261 (1.471-3.475) |
<0.001 | 1.817 (1.196-2.762) |
0.005 | 2.043 (1.340-3.115) |
0.001 | 1.339 (0.618-2.903) |
0.46 | ||
| Smoking status | ||||||||||||
| Former/Active vs Never | 1.226 (0.828-1.815) |
0.309 | 1.183 (0.806-1.736) |
0.391 | 0.78 (0.416-1.459) |
0.437 | ||||||
| Age (years) | ||||||||||||
| ≥ 65 vs < 65 | 1.164 (0.815-1.664) |
0.404 | 1.088 (0.765-1.545) |
0.64 | 0.892 (0.488-1.630) |
0.71 | ||||||
| Tumor site | ||||||||||||
| Non-oropharynx vs Oropharynx | 1.203 (0.710-2.038) |
0.492 | 1.11 (0.672-1.833) |
0.685 | 1.197 (0.501-2.860) |
0.686 | ||||||
| The AJCC 7th Stage | ||||||||||||
| I II-IV vs I-II | 2.985 (1.861-4.787) |
<0.001 | 3.113 (1.935-5.009) |
<0.001 | 2.912 (1.833-4.624) |
<0.001 | 3.06 (1.922-4.874) |
<0.001 | 1.971 (0.968-4.015) |
0.061 | 2.039 (1.001-4.153) |
0.05 |
Value presented as hazard ratio (95% confident interval), p-value corresponds to Cox regression analysis