Table 1.
Characteristics of Studies Included in Systematic Review and Meta-Analysis of JCV and BK viruses in Colorectal Cancer Cases
| Author/year | Location | Study Design | Number of participants(male/female) | Prevalence |
Age of study population | Type of virus/target | Control type | Cancer type | Detection test | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PCR | Nested-PCR | IHC | Real Time PCR | ISH | |||||||||||||||||||||||
| Sinagra et al. 2014(Sinagra et al., 2014) | Italy | Cohort | 7-12 | DNA:0.37 | Median 70 (59-87) | JC/DNA | Non-CRC(HCV) | Colorectal | Nested-PCR | ||||||||||||||||||
| Tsekov et al. 2011(Tsekov et al., 2011) | Bulgaria | Cross-Sectional | 29/15 | TAg:0.24 NCCR:0.0 | (Mean, range 65; 35-82) | JC/TAg & NCCR | Non-CRC Motivated Strategies for Learning Questionnaire (MSLQ (polyp) | Colorectal | Real time PCR | ||||||||||||||||||
| Theodoropoulos et al 2005(Theodoropoulos et al., 2005) | Greece | Cross-Sectional | 38/42 | DNA:0.61 | (Mean 62.75), (range, 35–82) (SD± 12.47) | JC/DNA | Adjacent mucosa- adenomatous- Non-CRC | Colon | Nested PCR | ||||||||||||||||||
| Matalka, 2013(Matalka et al., 2013) | Jordan | Cross-Sectional | 44/48 | DNA:0.94 TAg:0.43 | TAg:0.15 | Ages ranged from 20 to 86 years | JC/ TAg &DNA | Adenomatose, Non-CRC | Colorectal | PCR, IHC | |||||||||||||||||
| Hori et al.2005(Hori et al., 2005) | Japan | Cross-Sectional | 13/10 | TAg:0.26 | VP1:0.0 | Average age of 66.3 years (range40-85) | JC/ TAg& VP1 | Adenomatous & Non-CRC | Colorectal | Nested PCR & IHC | |||||||||||||||||
| Tae Jung,2008(Jung et al., 2008) | USA | cross -sectional | 22(both sex) | TAg:0.55 | ---- | JC/TAg | Adenomatose, Adjacent tissue | Colorectal | PCR& IHC | ||||||||||||||||||
| Niv. 2010(Niv et al., 2010b) | Israel | cross -sectional | 11(both sex) | TAg:0.36 | 66.9±11.1 | JC/TAg | Adenomatose | Colorectal | PCR | ||||||||||||||||||
| Toumi et al. 2017(Toumi et al., 2017) | Tunisia | Cross-Sectional | 24/23 | DNA:0.47 | (Mean age: 64-years) | JC/DNA | Adjacent mucosa- Non-CRC | Colorectal | Nested PCR | ||||||||||||||||||
| Tseng et al. 2014(Tseng et al., 2014) | Taiwan | Cross-Sectional | 1/2(JC) | DNA:0.0 | TAg:0 VP1:0 | Renge 65-84 | JC/DNA &TAg & VP1 | Adjacent mucosa | Colon | PCR & | |||||||||||||||||
| Casini,2005(Casini et al., 2005) | Italy | Case-control | 18(both sex) | DNA:0.83 | DNA:0.50 | ----- | JC/DNA | Adjacent tissue | Colorectal | PCR & ISH | |||||||||||||||||
| Lin,2008(Lin et al., 2008) | Taiwan | Cross -sectional | 13-Sep | DNA:0.86 | TAg:0.64 | 47-89 | JC/DNA& TAg (large tumor) | Adjacent tissue | Colon cancer | Nested PCR& IHC | |||||||||||||||||
| Enam,2002(Enam et al., 2002) | USA | Cross -sectional | 17-Oct | TAg:0.81 VP1:0.15 Agnoprotien:0.56 |
Agnoprotien:0.44 TAg:0.63 VP1:0.0 |
Range (41-91) | JC/TAg&VP1&Agnoprotein antibody | Adjacent tissue | Colon | PCR& IHC | |||||||||||||||||
| Vilkin . 2012(Vilkin et al., 2012) | Israeli | Cross-Sectional | 13/17 history& 13/13without history | TAg:0.20 | 80.9 ± 5.6 histories & 51.7 ± 6.2without history | JC/ TAg | Totally 2 groups(Family history & without a family history) | Colorectal | PCR | ||||||||||||||||||
| Mou, 2012(Mou et al., 2012) | China | Cross-Sectional | 74/63 | DNA:0.23 TAg:0.41 | Mean age in CRC patients 63 Non-CRC patients 49.6, Healthy donors 62.6 | JC /TAg & DNA | Healthy people, Adjacent tissue, Non-CRC | Colorectal | Nested PCR | ||||||||||||||||||
| Samaka,2012 (Samaka et al., 2013) | Egypt | Cross - sectional | 23/34 | TAg:0.66 | 47.8 ± 13.7 | JC/ TAg | Healthy people, Adenomatose | Colorectal | ISH | ||||||||||||||||||
| Samaka,2012 (Samaka et al., 2013) | Egypt | Cross - sectional | 23/34 | TAg:0.66 | 47.8 ± 13.7 | JC/ TAg | Healthy people, Adenomatose | Colorectal | ISH | ||||||||||||||||||
| Rasteiro Coelho,2013(Coelho et al., 2013) | Portugal | Case-control | 67/33 | DNA:0.90 | ---- | JC/DNA | Healthy people Adjacent tissue | Colorectal | Nested PCR | ||||||||||||||||||
| Ksiaa, 2015(Ksiaa et al., 2015) | North Africa | Cross -sectional | 60/45 | DNA:058 | Mean age 62 years (range 20-95). | JC/DNA | Healthy people | Colorectal | PCR | ||||||||||||||||||
| Navand1,2018(Haghi Navand et al., 2019) | Iran | Cross -sectional | 20/20 | DNA:0.10 | ---- | JC/DNA | Healthy people | Colorectal | PCR | ||||||||||||||||||
| Ripple,2014(Ripple et al., 2014) | USA | Cross-Sectional | 26/8 | TAg:0.62 | 35-76 | JC/ TAg | -- | Colorectal | IHC | ||||||||||||||||||
| Sarvari,2018(Sarvari et al., 2018) | Iran | Cross - sectional | 77/63 | DNA:0.0 | 52 ± 1.64 | JC / DNA | -- | Colorectal | PCR | ||||||||||||||||||
| Goel, 2006(Goel et al., 2006) | USA | Cross - sectional | 100(both sex) | TAg:0.77 | TAg:0.43 | ---- | JC/TAg | -- | Colorectal | PCR & IHC | |||||||||||||||||
| Giuliani,2008(Giuliani et al., 2008) | Italy | Cross -sectional | 66(both sex) | DNA:0.0 | ---- | JC /DNA | ---- | Colorectal | PCR | ||||||||||||||||||
| Niv, 2010(Niv et al., 2010a) | Israel | Cross -sectional | 24(both sex) | DNA:0.83 | 71.3±12.6 | JC/DNA | -- | Colorectal | PCR | ||||||||||||||||||
| Sarvari,2018(Sarvari et al., 2018) | Iran | Cross - sectional | 77/63 | DNA:0.0 | 52 ± 1.64 | BK/ DNA | -- | Colorectal | PCR | ||||||||||||||||||
| Giuliani,2008(Giuliani et al., 2008) | Italy | Cross -sectional | 66(both sex) | DNA:0.10 | ---- | BK/DNA | ---- | Colorectal | PCR | ||||||||||||||||||
| Jarzynski,2017(Jarzynski et al., 2017) | Poland | Cross - sectional | 24/26 | DNA:0.30 | 40 years and more | BK/DNA | ---- | Colorectal | PCR | ||||||||||||||||||
| Casini,2005(Casini et al., 2005) | Italy | Case-control | 18(both sex) | DNA:0.0 | ----- | BK/DNA | Adjacent tissue | Colorectal | PCR & ISH | ||||||||||||||||||
| Tseng et al. 2014(Tseng et al., 2014) | Taiwan | Cross-Sectional | 2-Jan | VPI:0.0 TAg:1.0 | Renge 65-84 | BK /DNA &TAg & VP1 | Adjacent mucosa | Colon | PCR &IHC | ||||||||||||||||||