Table 3.

The Relative Expression Level of p21Cip1/Waf1/Sdi1, p27Kip1, p57Kip2, DNMTs, HDAC1, HDAC2, and HDAC3 Genes

Cell line	Gene	Drug	Dose (μM)	Duration (h)	Expression	P-value
LS 180	DNMT1	Zebularine	2.5 μM	24	0.65	0.001
LS 180	DNMT1	Zebularine	25 μM	48	0.55	0.001
LS 180	DNMT3a	Zebularine	25 μM	24	0.61	0.001
LS 180	DNMT3a	Zebularine	25 μM	48	0.53	0.001
LS 180	DNMT3b	Zebularine	25 μM	24	0.58	0.001
LS 180	DNMT3b	Zebularine	25 μM	48	0.49	0.01
LS 180	P21	Zebularine	25 μM	24	2.3	0.004
LS 180	P21	Zebularine	25 μM	48	2.6	0.001
LS 180	P27	Zebularine	25 μM	24	2.4	0.001
LS 180	P27	Zebularine	25 μM	48	2.7	0.001
LS 180	P57	Zebularine	25 μM	24	2	0.001
LS 180	P57	Zebularine	25 μM	48	2.2	0.001
LS 180	HDAC1	Trichostatin A	5 μM	24	0.48	0.001
LS 180	HDAC1	Trichostatin A	5 μM	48	0.41	0.004
LS 180	HDAC2	Trichostatin A	5 μM	24	0.37	0.002
LS 180	HDAC2	Trichostatin A	5 μM	48	0.3	0.01
LS 180	HDAC3	Trichostatin A	5 μM	24	0.34	0.007
LS 180	HDAC3	Trichostatin A	5 μM	48	0.28	0.001
LS 180	P21	Trichostatin A	5 μM	24	3.1	0.001
LS 180	P21	Trichostatin A	5 μM	48	3.7	0.001
LS 180	P27	Trichostatin A	5 μM	24	2.9	0.001
LS 180	P27	Trichostatin A	5 μM	48	3.2	0.001
LS 180	P57	Trichostatin A	5 μM	24	2.8	0.001
LS 180	P57	Trichostatin A	5 μM	48	3	0.001