Table 4.
The Relative Expression Level of p21Cip1/Waf1/Sdi1, p27Kip1, p57Kip2 Genes with Combined Treatment
| Cell line | Gene | Drug | Dose (μM) | Duration (h) | Expression | P-value |
|---|---|---|---|---|---|---|
| LS 180 | P21 | Zebularine/TSA | 25/5 μM | 24 | 3.8 | 0.001 |
| LS 180 | P21 | Zebularine/TSA | 25/5 μM | 48 | 4.2 | 0.001 |
| LS 180 | P27 | Zebularine/TSA | 25/5 μM | 24 | 3.3 | 0.001 |
| LS 180 | P27 | Zebularine/TSA | 25/5 μM | 48 | 3.5 | 0.001 |
| LS 180 | P57 | Zebularine/TSA | 25/5 μM | 24 | 3.2 | 0.001 |
| LS 180 | P57 | Zebularine/TSA | 25/5 μM | 48 | 3.9 | 0.001 |