Table 1.
Sociodemographic Characteristics, Risk Factors, and Polymorphisms, GSTP1 A313G, GSTP1 C341T, GSTT1 and GSTM1 in Patients with Head and Neck Cancer and Controls
| Variables | Case n=197 (%) | Control n=514 (%) |
OR (95% CI) | P-value |
|---|---|---|---|---|
| Gender | ||||
| Female | 19 (10.0) | 145 (28.0) | 1 | 0.040 |
| Male | 178 (90.0) | 369 (72.0) | 2.13 (1.03-4.38) | |
| Age (Median) | ||||
| <59 | 97 (49.0) | 448 (87.0) | 1 | |
| ≥59 | 100 (51.0) | 66 (13.0) | 11.66 (6.51-20.86) | <0.001 |
| Smoking Habit | ||||
| Non-smoke | 20 (10.0) | 309 (60.0) | 1 | <0.001 |
| Smoke | 177 (90.0) | 205 (40.0) | 11.00 (5.71-21.20) | |
| Alcoholic Habit | ||||
| Non-alcoholic | 28 (14.0) | 260 (51.0) | 1 | <0.001 |
| Alcoholic | 169 (86.0) | 254 (49.0) | 4.14 (2.25-7.64) | |
| Polymorphisms | ||||
| GSTT1 | ||||
| +/+ | 140 (71.1) | 402 (78.2) | 1 | 0.610 |
| 0/0 | 57 (28.9) | 112 (21.8) | 1.14 (0.69-1.87) | |
| GSTM1 | ||||
| +/+ | 98 (49.8) | 275 (53.5) | 1 | 0.400 |
| 0/0 | 99 (50.2) | 239 (6.5) | 1.20 (0.78-1.85) | |
| GSTP1-A313G a | ||||
| Codominant | ||||
| A/A | 101 (56.7) | 227 (44.2) | 1 | 0.140 |
| A/G | 62 (34.8) | 221 (43) | 0.66 (0.41-1.05) | |
| G/G | 15 (8.4) | 66 (12.8) | 0.61 (0.29-1.25) | |
| Dominant | ||||
| A/A | 101 (56.7) | 227 (44.2) | 1 | 0.050 |
| A/G-G/G | 77 (43.3) | 287 (55.8) | 0.64 (0.42-1.00) | |
| Recessive | ||||
| A/A-A/G | 163 (91.6) | 448 (87.2) | 1 | 0.360 |
| G/G | 15 (8.4) | 66 (12.8) | 0.73 (0.36-1.46) | |
| Overdominant | ||||
| A/A-G/G | 116 (65.2) | 293 (57.0) | 1 | 0.16 |
| A/G | 62 (34.8) | 221 (43.0) | 0.72 (0.46-1.14) | |
| Additive | --- | --- | 0.74 (0.53-1.02) | 0.062 |
| GSTP1-C341T b | ||||
| Codominant | ||||
| C/C | 173 (89.6) | 460 (89.5) | 1 | 0.260 |
| C/T | 20 (10.4) | 50 (9.7) | 0.80 (0.40-1-60) | |
| T/T | 0 (0) | 4 (0.8) | 0 | |
| Dominant | ||||
| C/C | 173 (89.6) | 460 (89.5) | 1 | 0.380 |
| C/T - T/T | 20 (10.4) | 54 (10.5) | 0.74 (0.37-1.46) | |
| Recessive | ||||
| C/C - C/T | 193 (100) | 510 (99.2) | 1 | 0.150 |
| T/T | 0 (0) | 4 (0.8) | 0 | |
| Overdominant | ||||
| C/C - T/T | 173 (89.6) | 464 (90.3) | 1 | 0.550 |
| C/T | 20 (10.4) | 50 (9.7) | 0.81, (0.41-1.62) | |
| Additive | --- | --- | 0.70 (0.37-1.33) | 0.270 |
a, Odds Ratio (OR) adjusted for age, gender, and alcohol and smoking habits and polymorphisms significant p values for p <0.05 a Amplification was possible for 692 individuals of the case group bAmplification was possible for 707 individuals of the case groupd.