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. Author manuscript; available in PMC: 2020 Oct 18.
Published in final edited form as: Transl Res. 2019 Dec 25;218:16–28. doi: 10.1016/j.trsl.2019.12.002

Figure 6.

Figure 6.

Activity testing of NHC in a Ca/09-derived minigenome reporter assay, comparing unmodified polymerase complexes (Ca/09 standard) and complexes harboring two substitutions reportedly mediating resistance to favipiravir (Ca/09 KR + PL, carrying mutations PB1 K229R and PA P653L) [25, 26]. Symbols show biological repeats (n = 3) for each concentration tested, lines represent four-parameter variable slope regression models. EC50 concentrations are specified, 95% confidence intervals in parentheses.