Table 1.
Comparison of Clinicopathological Characteristics Among Elderly CRC Patients with Overall Postoperative Complications (POCs; CDC grade II–V) and Unremarkable-Recovery POCs (CDC grade 0–I), n=614
| CDC 0–I | CDC II–V | P-value | |
|---|---|---|---|
| n (%) | 459 (100) | 155 (100) | |
| CCI scores | 0 (0–12.25) | 20.92 (20.92–100) | <0.001 |
| Age (years), median (Q1–Q3)] | 74 (70–78) | 76 (72–79) | <0.001 |
| Sex | 0.006 | ||
| Female | 171 (37) | 77 (50) | |
| Male | 288 (63) | 78 (50) | |
| Smoking | 0.517 | ||
| No | 338 (74) | 110 (71) | |
| Yes | 121 (26) | 45 (29) | |
| Drinking | 0.822 | ||
| No | 371 (81) | 124 (80) | |
| Yes | 88 (19) | 31 (20) | |
| Hypertension | 0.054 | ||
| No | 263 (57) | 75 (48) | |
| Yes | 196 (43) | 80 (52) | |
| Diabetes | 0.414 | ||
| No | 381 (83) | 133 (86) | |
| Yes | 78 (17) | 22 (14) | |
| Coronary heart diseases | 0.005 | ||
| No | 419 (91) | 129 (83) | |
| Yes | 40 (9) | 26 (17) | |
| History of malignancy | 0.565 | ||
| No | 435 (95) | 145 (94) | |
| Yes | 24 (5) | 10 (6) | |
| Family history of tumors | 0.050 | ||
| No | 435 (95) | 140 (90) | |
| Yes | 24 (5) | 15 (10) | |
| Bowel-habit changes | 0.766 | ||
| No | 356 (78) | 122 (79) | |
| Yes | 103 (22) | 33 (21) | |
| Abdominal pain | 0.752 | ||
| No | 358 (78) | 119 (77) | |
| Yes | 101 (22) | 36 (23) | |
| Obstruction | 0.153 | ||
| No | 418 (91) | 135 (87) | |
| Yes | 41 (9) | 20 (13) | |
| Preoperative anemia | 0.001 | ||
| No | 270 (59) | 68 (44) | |
| Yes | 189 (41) | 87 (56) | |
| CEA level | 0.868 | ||
| Low | 270 (59) | 90 (58) | |
| High | 189 (41) | 65 (42) | |
| Surgery procedure | 0.003 | ||
| Open | 258 (56) | 108 (70) | |
| Laparoscopic | 201 (44) | 47 (30) | |
| Amount of bleeding | 0.028 | ||
| Low | 208 (45) | 57 (37) | |
| Moderate | 211 (46) | 74 (48) | |
| High | 40 (9) | 24 (15) | |
| Tumor location | 0.061 | ||
| Colon | 282 (61) | 82 (53) | |
| Rectum | 177 (39) | 73 (47) | |
| T stage | 0.506 | ||
| T1 | 17 (4) | 4 (3) | |
| T2 | 57 (12) | 24 (15) | |
| T3 | 232 (51) | 70 (45) | |
| T4 | 153 (33) | 57 (37) | |
| N stage | 0.311 | ||
| N0 | 266 (58) | 97 (63) | |
| N1–N2 | 193 (42) | 58 (37) | |
| M stage | 0.491 | ||
| M0 | 420 (92) | 139 (90) | |
| M1 | 39 (8) | 16 (10) | |
| Tumor size | 0.041 | ||
| Small | 230 (50) | 63 (41) | |
| Large | 229 (50) | 92 (59) | |
| LNR | 0.015 | ||
| Low | 311 (68) | 121 (78) | |
| High | 148 (32) | 34 (22) | |
| Differentiation | 0.987 | ||
| Low | 25 (5) | 8 (5) | |
| Moderate | 255 (56) | 87 (56) | |
| High | 179 (39) | 60 (39) | |
| Neurovascular tumor embolus | 0.534 | ||
| Negative | 411 (90) | 136 (88) | |
| Positive | 48 (10) | 19 (12) | |
| Tumor nodules | 0.984 | ||
| Absent | 355 (77) | 120 (77) | |
| Present | 104 (23) | 35 (23) | |
| Postoperative chemotherapy cycles | 0.003 | ||
| 0–≤2 | 283 (62) | 116 (75) | |
| 3–8 | 176 (38) | 39 (25) |
Abbreviations: CRC, colorectal cancer; CDC, Clavien–Dindo classification; CCI, comprehensive complication index; LNR, (positive dissected) lymph-node ratio; OS, overall survival.