Table 4.

Associations of Postoperative Complications with OS Analyzed by Multivariate Cox Regression Models in Elderly Patients After Radical CRC Surgery in PSM Cohort and Entire Cohort, Excluding Patients with CDC V POCs

	Postoperative complications	HR	95% CI		P value
PSM cohort (n=309)
Unadjusted	Overall POCs (CDC II–IV vs 0–I)	1.621	1.084	2.425	0.019
Adjusted§	Overall POCs (CDC II–IV vs 0–I)	1.751	1.140	2.691	0.011
Unadjusted	CCI scores (per 1-point increase)	1.019	1.006	1.033	0.005
Adjusted§	CCI scores (per 1-point increase)	1.017	1.003	1.030	0.014
Entire cohort* (n=601)
Unadjusted	Overall POCs (CDC II–IV vs 0–I)	1.520	1.097	2.107	0.012
Adjusted†	Overall POCs (CDC II–IV vs 0–I)	1.558	1.075	2.258	0.019
Unadjusted	CCI scores (per 1-point increase)	1.017	1.006	1.029	0.004
Adjusted†	CCI scores (per 1-point increase)	1.017	1.004	1.030	0.012

Notes: ^§Adjusted for age, smoking, history of malignancy, obstruction, CEA levels, T stage, N stage, tumor size, LNR, tumor nodules, tumor differentiation, and postoperative chemotherapy; ^†adjusted for age, smoking, history of malignancy, family history of tumors, abdominal pain, obstruction, preoperative anemia, CEA levels, surgery procedure, amount of bleeding, T stage, N stage, tumor size, LNR, tumor nodules, tumor differentiation, and postoperative chemotherapy; *excluding patients with CDC V POCs (n=13).

Abbreviations: CRC, colorectal cancer; CDC, Clavien–Dindo classification; CCI, comprehensive complication index; LNR, (positive dissected) lymph-node ratio; OS, overall survival.