Table 5.

Multivariate Stepwise Cox Proportional Hazard–Regression Models Incorporating CDC or CCI for Predicting OS in Elderly Patients After Radical CRC Surgery (PSM Cohort, n=309)

	HR	95% CI		P-value	C-index
CDC					0.7548
Overall POCs (CDC II–IV vs 0–I)	1.597	1.058	2.410	0.026
Age (years), continuous	1.039	1.001	1.079	0.047
Smoking (yes vs no)	1.678	1.108	2.540	0.015
History of malignancy (yes vs no)	2.251	1.158	4.377	0.017
CEA levels (high vs low)	1.763	1.157	2.686	0.008
N stage (N1–N2 vs N0)	1.623	0.929	2.833	0.089
Tumor size (large vs small)	1.178	0.949	1.463	0.138
LNR (high vs low)	1.923	1.132	3.266	0.016
Tumor nodules (present vs absent)	1.760	1.093	2.832	0.020
Postoperative chemotherapy cycles (3–8 vs ≤2)	0.652	0.514	0.827	0
CCI					0.7533
CCI score (continuous)	1.014	1.001	1.027	0.031
Age (years), continuous	1.038	1.000	1.078	0.050
Smoking (yes vs no)	1.660	1.093	2.521	0.017
History of malignancy (yes vs no)	2.138	1.099	4.159	0.025
CEA levels (high vs low)	1.844	1.209	2.812	0.005
N stage (N1–N2 vs N0)	1.591	0.908	2.785	0.104
Tumor size (large vs small)	1.156	0.931	1.434	0.190
LNR (high vs low)	1.904	1.124	3.228	0.017
Tumor nodules (present vs absent)	1.736	1.080	2.789	0.023
Postoperative chemotherapy cycles (3–8 vs ≤2)	0.656	0.516	0.834	0.001

Abbreviations: CRC, colorectal cancer; CDC, Clavien–Dindo classification; CCI, comprehensive complication index; LNR, (positive dissected) lymph-node ratio; OS, overall survival.