Table 4.
Associations between baseline NfL levels and cognitive performance in patients with follow-up
| Variable | Baseline cognition |
Future cognition |
||
|---|---|---|---|---|
| β (95% CI) | P | β (95% CI) | P | |
| Cognitive performance | ||||
| Cognitive index | –0.160 (–0.184 to –0.045) | 0.001 | –0.145 (–0.206 to –0.057) | 0.001 |
| Memory | –0.130 (–0.169 to –0.018) | 0.016 | –0.136 (–0.212 to –0.045) | 0.003 |
| Processing speed | –0.204 (–0.262 to –0.090) | <0.001 | –0.159 (–0.242 to –0.068) | 0.001 |
| Executive function | –0.080 (–0.137 to 0.012) | 0.101 | –0.095 (–0.170 to –0.007) | 0.033 |
Associations between NfL levels and cognitive performance for all participants who completed repeated cognitive assessments (n=336), presented as standardized betas with 95% CIs, analyzed by linear regression analyses. NfL levels were log-transformed. P-values, adjusted for age, sex, education, and depressive symptoms.
NfL, neurofilament light; CI, confidence interval.