Table 1.

Mechanisms behind impaired platelet function and endothelium interaction in end-stage renal disease

Mechanisms of platelet dysfunction [30]
	Impairment of arachidonic acid and prostaglandin metabolism
	Disturbance of platelet α-granules
	Impairment of thromboxane A2 synthesis and/or release
	Competitive binding of circulating fibrinogen fragments to glycoprotein IIb/IIIa receptor on platelets
	Uremic toxins, oxidative stress and inflammatory state
Mechanisms of impaired interaction between platelet and endothelium [30]
	Decrease in platelet GPIb receptor
	Inadequate binding of vWF and fibrinogen to activated platelets
	Increased level of prostacyclin and nitric oxide

GP1b, glycoprotein 1b; vWF, von-Willebrand factor.