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. 2020 Oct 14;12:579–588. doi: 10.2147/CEOR.S268553

Table 1.

Input Parameters Used in the Model

Parameters Value Range Reference
Probabilities Used in the Model
Short-term model
Death 0.0048 0.0015–0.0081 Colquitt et al21
Failure 0.0840 0.0700–0.0970 Colquitt et al21
Complication 0.1063 0.0957–0.1169 Fox et al20
Long-term model
 Risk of CV mortality 0.0174 Bristow et al11
 Relative risk of CV death
(CRT vs OMT)		 0.67 0.51–0.88 Colquitt et al21
 Risk of CV death from hospitalization
  OMTa
  CRTb 		0.0001
0.0001		 0.0001–0.0002
0.0001–0.0001		 Calculation
 Risk of CV death from non-hospitalization
  OMTc
  CRTd 		0.0172
0.0116		 0.0155–0.0190
0.0104–0.0127		 Calculation
 Risk of non-CV death from hospitalization 0.0083 0.0075–0.0091 Krittayaphong et al4
 Risk of non-CV death from non-hospitalization
  65
  70
  75
  80
  85
  90
  95
  100
0.0052
0.0080
0.0128
0.0203
0.0357
0.0357
0.0357
0.0357		 Burden of disease in Thai population35 Health statistics36
 Risk of hospitalization OMT 0.037 0.025–0.049 Colquitt et al21
 Risk of all-cause 30-day readmission 0.2882 0.2594–0.3171 Thailand database22
 Risk of infection 0.0006 0–0.0020 Colquitt et al21
 Risk of lead displacement 0.0037 0.0033–0.0041 Colquitt et al21
 Relative risk of hospitalization
(CRT vs OMT)		 0.58 0.35–0.96 Colquitt et al21
Costs (THB/USD per cycle)
 CRT 367,710
(11,850.15)		 294,168–441,252
(9,480.12–14,220.17)		 Hospital database23
 OMT 3,048
(98.23)		 2,438–3,658
(78.57–117.89)
 Hospitalization 10,518
(338.96)		 8,414–12,621
(271.16–406.74)
 Infection 47,062
(1,516.66)		 37,650–56,474
(1,213.34–1,819.98)
 Lead displacement 10,518
(338.96)		 8,414–12,621
(271.16–406.74)
 Perioperative complications 32,000
(1,031.26)		 25,600–38,400
(825.01–1,237.51)
Utilities
 HF stable 0.750 0.675–0.825 Adena et al23
 Hospitalization 0.650 0.585–0.715 Adena et al23
 CRT implantation 0.460 0.414–0.506 Neyt et al37
 Disutility of infection 0.1 0.09–0.11 Colquitt et al21

Notes: a1-month rate of CV death from COMPANION trial = -(In (1–18.83%))/11.9=1.75%; 1-month rate of CV death in hospital in Thailand = -(In (1–9.73%))/12=0.82%; 1-month rate of CV death in hospital in this study = -(In (1–9.73%))/12 =1.75%*0.82%=0.01%; Probability of CV death in hospital = 1-exp(−0.01%)=0.0001; b1-month rate of CV death from COMPANION trial = 1.75%*0.67=1.17% (HR 0.67); 1-month rate of CV death in hospital in Thailand = -(In (1–9.73%))/12=0.82%; 1-month rate of CV death in hospital in this study =1.17%*0.82%=0.01%; Probability of CV death in hospital = 1-exp(−0.01%)=0.0001; c1-month probability of CV death = 1-exp(−1.75%)=0.017; 1-month probability of CV death from non-hospitalization = 0.017–0.0001=0.0172; d1-month probability of CV death = 1-exp(−1.17%)=0.012; 1-month probability of CV death from non-hospitalization = 0.012–0.0001=0.0116.

Abbreviations: CRT, cardiac resynchronization therapy; CV, cardiovascular; OMT, optimal medical therapy; HR, hazard ratio; HF, heart failure; THB, Thai baht; USD, United States dollars.