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. 2020 Oct 14;12:10113–10125. doi: 10.2147/CMAR.S271807

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© 2020 Lin et al.

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Immunotherapeutic response related-factor analysis in the cohort TCGA. (A) Spearman correlation of CBX3 with the abundance of TILs in gastric cancer (TIMER). (B) Relationships between CBX3 expression and neoantigen and TMB. (C) Spearman correlation between PDCD1, PDCD1LG2, CD274, CTLA4 and CBX3 expression in gastric cancer. (D) Distribution of MSI status in high and low CBX3 groups. (E) The expression difference of CBX3 between the anti-PD-1 immunotherapy response and progression groups in the GEO combine dataset (n=43). (F and G) Differences in CBX3 expression between the immune checkpoint blockade response and nonresponse groups in TCGA-STAD and GEO-GC cohorts. P value designations: *P < 0.05, **P < 0.01, ****P<0.0001.

Abbreviations: TILs, tumor-infiltrating lymphocytes; TMB, tumor mutational burden; MSI, microsatellite instability.