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. 2020 Oct 14;12:10151–10161. doi: 10.2147/CMAR.S263768

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© 2020 Wang et al.

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SFRP1 is a functional downstream target of miR-582-3p. (A) Prediction binding sites of miR-582-3p in the 3ʹUTR sequence of SFRP1. (B and C) miR-582-3p mimics or miR-582-3p-exos decreased the expression of SFRP1 protein in normoxic A549 cells. (D and E) Luciferase activity in A549 and H1299 cells co-transfected with wild-type (WT) or mutant (MUT) SFRP1 3ʹUTR reporter and miR-582-3p mimics or miR-NC. (F and G) Luciferase activity of WT or MUT SFRP1 3ʹUTR reporter in A549 and H1299 cells treated with miR-582-3p-exos or NC-exos. The experiments were repeated three times. Data were expressed as mean±standard deviation. *p<0.05, **p<0.01, and ***p<0.001.