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. 2020 Oct 16;40(10):BSR20190337. doi: 10.1042/BSR20190337

Figure 1. Pathogenic Cryptococcus species.

Figure 1

Relatedness of the (A) Cryptococcus species complex and (B) subpopulations within C. neoformans. (A) There are five proposed species in the C. gattii species complex (yellow), and two species in the C. neoformans species complex (blue) [1,2,20]. (B) There are three evolutionarily distinct subpopulations within C. neoformans, as defined by molecular type: VNI, VNII, and VNB. VNII is very rarely found in clinical isolates. VNB is more diverse, was initially discovered in Botswana, and patients infected with these strains tend to have poor clinical outcomes. VNI causes the most cases of cryptococcosis and has three evolutionarily distinct subpopulations; ST93 and ST5 are in separate subpopulations [21,54,55].